Сенников Сергей Витальевич

Sergey V. Sennikov

M.D., Ph.D., D.Sc., professor

Head of the laboratory of molecular Immunology,

Research Institute of fundamental and clinical Immunology

Novosibirsk, Russia

Address Research Institute of Fundamental and Clinical Immunology (RIFCI), 630099 Novosibirsk, Russia

Email sennikovsv@gmail.com

Phone +7 383 222 1910

H-index 14 WOS ResearcherID O-2164-2013

ORCID 0000-0002-7366-7768 Scopus ID 7004762032

Research Interests: Cellular Immunology, Molecular Immunology, OncoImmunology, Cytokines, Immunoregulation, Autoimmunity, Inflammation

Education & Experience

1978-1984 Graduated from Siberian State Medical University (Tomsk, Russia) with specialty Biochemistry

1984-1987 Completed postgraduate course in Research Institute of Fundamental and Clinical Immunology (RIFCI), Novosibirsk, Russia.

1988 Received a Ph.D. degree in Medical Sciences (specialty Allergology and Immunology, thesis “Influence of erythroblasts on reactions of humoral and cell mediated immunity”).

1988 – 2004 Worked as research fellow in RIFCI, Novosibirsk, Russia.

2002 Received a D.Sc. degree in Medical Sciences with thesis “Cytokine synthesizing activity of erythroid nucleated cells”.

2004 – present Founded and headed the Laboratory of molecular immunology in RIFCI

2004 – 2015 Was a deputy director for scientific efforts in RIFCI, Novosibirsk, Russia.

2015 – 2018 Head of the RIFCI, Novosibirsk, Russia

2005 Was promoted to the rank of professor in Allergology and Immunology specialty.

2018-2020 Founded and headed the Laboratory of cell technologies in Immunotherapy in Novosibirsk State University (NSU), Novosibirsk, Russia.

2018 – present Lecturer of the Cell Technology in Immunotherapy Course in V. Zelman institute for the medicine and psychology, NSU, Novosibirsk, Russia.

Research project management

(Last 3 years)

2019-2020 "Development of a cellular technology for suppressing immune reactions of rejection of transplanted tissues" (extension) Russian Science Foundation (RSF). No. 16-15-00086 P.

2019 "United Immunological Forum-2019". Russian Foundation for Basic Research project No. 19-015-20003 (scientific events).

2016-2020 "Development of a cell technology for suppressing immune reactions of rejection of transplanted tissues" RSF agreement No. 16-15-00086.

2021-2023 “Investigation of cytokine synthesizing activity and and immunoregulatory role of erythroid nucleated cells” RSF agreement No. 21-15-00087

Additional activities

• Supervised 22 Ph.D. and 2 D.Sc. dissertations, currently supervise 5 PhD students

• Member of the Russian Society of Immunology, European Federation of Immunological Societies;

• Member of the Russian Cytokine Society;

• Member of academic council and dissertation commission in RIFCI (Allergology and Immunology specialty, commission reg number D001.001.01)

• Member of Editorial board in journals

o Frontiers in Bioscience-Landmark

o Mathews Journal of Immunology & Allergy

o Gavin Journal of Oncology Research and Therapy

o Henry Journal of Cellular & Molecular Oncology

o American Journal of Arthritis

o Trends in Immunotherapy

o Cytokines and Inflammation (Russian)

o Russian journal of Immunology (Russian)

o Immunologiya (Russian)

Key publications

(last 3 years)

1. Shevchenko JA, Khristin AA, Kurilin VV, Kuznetsova MS, Blinova DD, Starostina NM, Sidorov SV, Sennikov SV. Autologous dendritic cells and activated cytotoxic T‑cells as combination therapy for breast cancer. // Oncol Rep. 2020 Feb;43(2):671-680. doi: 10.3892/or.2019.7435. Epub 2019 Dec 16. PMID: 31894312

2. Alshevskaya A, Lopatnikova J, Zhukova J, Chumasova O, Shkaruba N, Sizikov A, Evsegneeva I, Gladkikh V, Karaulov A, Sennikov SV. "Co-expression profile of TNF membrane-bound receptors type 1 and 2 in rheumatoid arthritis on immunocompetent cells subsets" // Int. J. Mol. Sci. 2020, 21(1), 288; https://doi.org/10.3390/ijms21010288 (IF 4.183; Q1)

3. Sennikov S.V., Tereshchenko V.P., Kurilin V.V., Shevchenko J.A., Lopatnikova J.A., Silkov A.N., Maksyutov A.Z., Kuznetsova M.S., Knauer N.Y., Bulygin A.S., Khantakova J.N., "Dendritic Cells Transfected with MHC Antigenic Determinants of CBA Mice Induce Antigen-Specific Tolerance in C57Bl/6 Mice", Journal of Immunology Research, vol. 2020, Article ID 9686143, 13 pages, 2020. https://doi.org/10.1155/2020/9686143

4. Tereshchenko V, Bulygin A, Zavodskii R, Maksyutov A, Kurilin V, Fisher M, Semenyuk N, Aladev S, Sennikov S. The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo. Cytokine. 2021 Jun;142:155473. doi: 10.1016/j.cyto.2021.155473. Epub 2021 Feb 26. PMID: 33647585 (IF 2.952; Q1)

5. Shevyrev D, Tereshchenko V, Kozlov V, Sennikov S. Phylogeny, Structure, Functions, and Role of AIRE in the Formation of T-Cell Subsets. Cells. 2022; 11(2):194. https://doi.org/10.3390/cells11020194

6. Khantakova, J.N.; Bulygin, A.S.; Sennikov, S.V. The Regulatory-T-Cell Memory Phenotype