Javvadi, Yamini

I am spearheading a crucial initiative to comprehend and combat antibiotic resistance in diverse ecosystems. Our comprehensive research focuses on five pivotal objectives. We begin with genomic surveillance, utilizing a wastewater-based epidemiological approach to track antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in urban, semi-urban, and rural environments. This involves analyzing the occurrence and prevalence of ARGs linked to commonly used antibiotics, evaluating resistance transmission via mobile elements, and gaining insights into the dynamics of ARGs within these communities. Additionally, we conduct spatiotemporal surveillance to assess dominant resistant lineages, identifying core and persistent resistance patterns across different locations and over time. Through whole-genome metagenome sequencing, we delve into the resistome, uncovering the emergence of novel resistance and pathogen clusters, and providing crucial insights into prevailing resistant strains and emerging pathogens. We also explore innovative treatment methods, including aerobic-anaerobic-anoxic interface, electrochemical, and wetland systems, to effectively combat environmental resistance. Our ultimate goal is to translate this wealth of data into precise, evidence-based recommendations for clinical decision-making and initial empirical therapy choices, which are essential for ensuring optimal health management within our community. I am deeply passionate about making a tangible impact in the fight against antibiotic resistance. I eagerly anticipate sharing the progress and insights garnered from this project with the scientific and healthcare communities. Together, we can pave the way towards more effective resistance management and improved public health outcomes. #AntibioticResistance #PublicHealth #GenomicSurveillance #HealthcareInnovation