Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery
Publication type: Journal Article
Publication date: 2003-05-27
scimago Q2
wos Q3
SJR: 0.572
CiteScore: 5.8
Impact factor: 2.8
ISSN: 00218995, 10974628
Materials Chemistry
Surfaces, Coatings and Films
General Chemistry
Polymers and Plastics
Abstract
There have been many attempts to use anionic hydrogels as oral protein delivery carriers because of their pH-responsive swelling behavior. The dynamic swelling behavior of poly(methacrylic acid-co-methacryloxyethyl glucoside) and poly(methacrylic acid-g-ethylene glycol) hydrogels was investigated to determine the mechanism of water transport through these anionic hydrogels. The exponential relation Mt/M∞ = ktn (where Mt is the mass of water absorbed at time t and M∞ is the mass of water absorbed at equilibrium) was used to calculate the exponent (n) describing the Fickian or non-Fickian behavior of swelling polymer networks. The mechanism of water transport through these gels was significantly affected by the pH of the swelling medium. The mechanism of water transport became more relaxation-controlled in a swelling medium of pH 7.0, which was higher than pKa of the gels. The experimental results of the time-dependent swelling behaviors of the gels were analyzed with several mathematical models. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 1606–1613, 2003
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Total citations:
233
Citations from 2024:
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(6.44%)
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GOST
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Kim B. et al. Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery // Journal of Applied Polymer Science. 2003. Vol. 89. No. 6. pp. 1606-1613.
GOST all authors (up to 50)
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Kim B., La Flamme K., Peppas N. A. Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery // Journal of Applied Polymer Science. 2003. Vol. 89. No. 6. pp. 1606-1613.
Cite this
RIS
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TY - JOUR
DO - 10.1002/app.12337
UR - https://doi.org/10.1002/app.12337
TI - Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery
T2 - Journal of Applied Polymer Science
AU - Kim, Bumsang
AU - La Flamme, Kristen
AU - Peppas, Nicholas A.
PY - 2003
DA - 2003/05/27
PB - Wiley
SP - 1606-1613
IS - 6
VL - 89
SN - 0021-8995
SN - 1097-4628
ER -
Cite this
BibTex (up to 50 authors)
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@article{2003_Kim,
author = {Bumsang Kim and Kristen La Flamme and Nicholas A. Peppas},
title = {Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery},
journal = {Journal of Applied Polymer Science},
year = {2003},
volume = {89},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002/app.12337},
number = {6},
pages = {1606--1613},
doi = {10.1002/app.12337}
}
Cite this
MLA
Copy
Kim, Bumsang, et al. “Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery.” Journal of Applied Polymer Science, vol. 89, no. 6, May. 2003, pp. 1606-1613. https://doi.org/10.1002/app.12337.