A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging
Publication type: Journal Article
Publication date: 2017-02-23
scimago Q3
wos Q3
SJR: 0.488
CiteScore: 4.5
Impact factor: 3.2
ISSN: 21911630, 21911649
Bioengineering
Biomedical Engineering
Abstract
We present a new efficient method of incorporation of gadolinium chelates into polymeric shell surrounding liquid nanoparticles of perfluorotributylamine, which does not degrade the particles stability. The payload reaches ca. 105 Gd ions per nanoparticle giving large local concentration of contrast agent. The relaxivity of Gd-loaded nanoparticles estimated by magnetic resonance imaging at 7 T magnetic field is as high as 105–106 mM−1 s−1. These nanoparticles are promising for dual-mode imaging simultaneously on two nuclei 1H and 19F, thus enhancing the quality of visualization.
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Gervits L. L. et al. A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging // BioNanoScience. 2017. Vol. 7. No. 3. pp. 456-463.
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Gervits L. L., Shibaev A. V., Gulyaev M. V., Molchanov V. S., Anisimov N. V., Pirogov Y. A., Khokhlov A. R., Philippova O. E. A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging // BioNanoScience. 2017. Vol. 7. No. 3. pp. 456-463.
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TY - JOUR
DO - 10.1007/s12668-017-0400-8
UR - http://link.springer.com/10.1007/s12668-017-0400-8
TI - A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging
T2 - BioNanoScience
AU - Gervits, Lev L.
AU - Shibaev, Andrey V
AU - Gulyaev, Mikhail V
AU - Molchanov, Vyacheslav S
AU - Anisimov, Nikolai V
AU - Pirogov, Yury A.
AU - Khokhlov, Alexei R.
AU - Philippova, Olga E
PY - 2017
DA - 2017/02/23
PB - Springer Nature
SP - 456-463
IS - 3
VL - 7
SN - 2191-1630
SN - 2191-1649
ER -
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BibTex (up to 50 authors)
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@article{2017_Gervits,
author = {Lev L. Gervits and Andrey V Shibaev and Mikhail V Gulyaev and Vyacheslav S Molchanov and Nikolai V Anisimov and Yury A. Pirogov and Alexei R. Khokhlov and Olga E Philippova},
title = {A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging},
journal = {BioNanoScience},
year = {2017},
volume = {7},
publisher = {Springer Nature},
month = {feb},
url = {http://link.springer.com/10.1007/s12668-017-0400-8},
number = {3},
pages = {456--463},
doi = {10.1007/s12668-017-0400-8}
}
Cite this
MLA
Copy
Gervits, Lev L., et al. “A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging.” BioNanoScience, vol. 7, no. 3, Feb. 2017, pp. 456-463. http://link.springer.com/10.1007/s12668-017-0400-8.