BioNanoScience, издание 7, том 3, номера страниц: 456-463

A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging

Gervits Lev L. 1
, 
Shibaev Andrey V 2
, 
Gulyaev Mikhail V 2
, 
Molchanov Vyacheslav S 2
, 
Anisimov Nikolai V 2
, 
Pirogov Yury A. 2
, 
Khokhlov Alexei R. 2
, 
Philippova Olga E 2
1
 
2
 
Тип публикации: Journal Article
Дата публикации: 2017-02-23
Springer Nature
Springer Nature
Журнал:  BioNanoScience
Квартиль SCImago: Q3
Квартиль WOS: —
Impact factor: 2.9
ISSN: 21911630, 21911649
Bioengineering
Biomedical Engineering
Краткое описание
We present a new efficient method of incorporation of gadolinium chelates into polymeric shell surrounding liquid nanoparticles of perfluorotributylamine, which does not degrade the particles stability. The payload reaches ca. 105 Gd ions per nanoparticle giving large local concentration of contrast agent. The relaxivity of Gd-loaded nanoparticles estimated by magnetic resonance imaging at 7 T magnetic field is as high as 105–106 mM−1 s−1. These nanoparticles are promising for dual-mode imaging simultaneously on two nuclei 1H and 19F, thus enhancing the quality of visualization.
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1. Gervits L.L. и др. A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging // BioNanoScience. 2017. Т. 7. № 3. С. 456–463.
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TY - JOUR

DO - 10.1007/s12668-017-0400-8

UR - http://dx.doi.org/10.1007/s12668-017-0400-8

TI - A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging

T2 - BioNanoScience

AU - Gervits, Lev L.

AU - Shibaev, Andrey V.

AU - Gulyaev, Mikhail V.

AU - Molchanov, Vyacheslav S.

AU - Anisimov, Nikolai V.

AU - Pirogov, Yury A.

AU - Khokhlov, Alexei R.

AU - Philippova, Olga E.

PY - 2017

DA - 2017/02/23

PB - Springer Science and Business Media LLC

SP - 456-463

IS - 3

VL - 7

SN - 2191-1630

SN - 2191-1649

ER -

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@article{2017,

doi = {10.1007/s12668-017-0400-8},

url = {https://doi.org/10.1007%2Fs12668-017-0400-8},

year = 2017,

month = {feb},

publisher = {Springer Science and Business Media {LLC}},

volume = {7},

number = {3},

pages = {456--463},

author = {Lev L. Gervits and Andrey V. Shibaev and Mikhail V. Gulyaev and Vyacheslav S. Molchanov and Nikolai V. Anisimov and Yury A. Pirogov and Alexei R. Khokhlov and Olga E. Philippova},

title = {A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging}

}

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Gervits, Lev L. et al. “A Facile Method of Preparation of Polymer-Stabilized Perfluorocarbon Nanoparticles with Enhanced Contrast for Molecular Magnetic Resonance Imaging.” BioNanoScience 7.3 (2017): 456–463. Crossref. Web.