Journal of Chromatography B Biomedical Sciences and Applications, volume 714, issue 2, pages 119-126
Enantioselective multidimensional gas chromatography–mass spectrometry in the analysis of urinary organic acids
Publication type: Journal Article
Publication date: 1998-09-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 03784347
General Chemistry
Abstract
Enantioselective multidimensional gas chromatography-mass spectrometry is a valuable tool for the enantioselective analysis of compounds from complex matrices. Samples are separated initially on a precolumn and selected substances then transferred on-line to a main-column coated with suitable chiral stationary phase for enantioselective analysis with subsequent mass selective detection. In this paper the method is used as an adjunct to urinary organic acid analysis to provide information in patients with suspected inborn errors of metabolism. Lactic acid, alpha-hydroxyisocaproic acid, 3-phenyllactic acid and 3-(4-hydroxyphenyl)-lactic acid are separated in a single run. In addition, the enantioselective analysis of pyroglutamic acid is presented. D-Enantiomers of amino acids and alpha-hydroxycarboxylic acids derived from amino acids, point to a bacterial origin whereas the L-enantiomer is predominantly of endogenous origin. Therefore the enantiomeric ratio of chiral metabolites is an important parameter for the understanding of metabolic processes.
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GOST
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Heil M. et al. Enantioselective multidimensional gas chromatography–mass spectrometry in the analysis of urinary organic acids // Journal of Chromatography B Biomedical Sciences and Applications. 1998. Vol. 714. No. 2. pp. 119-126.
GOST all authors (up to 50)
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Heil M., Podebrad F., Beck T., Mosandl A., Sewell A. C., Böhles H. Enantioselective multidimensional gas chromatography–mass spectrometry in the analysis of urinary organic acids // Journal of Chromatography B Biomedical Sciences and Applications. 1998. Vol. 714. No. 2. pp. 119-126.
Cite this
RIS
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TY - JOUR
DO - 10.1016/S0378-4347(98)00233-3
UR - https://doi.org/10.1016/S0378-4347(98)00233-3
TI - Enantioselective multidimensional gas chromatography–mass spectrometry in the analysis of urinary organic acids
T2 - Journal of Chromatography B Biomedical Sciences and Applications
AU - Heil, Martin
AU - Podebrad, Frank
AU - Beck, Thomas
AU - Mosandl, Armin
AU - Sewell, Adrian C.
AU - Böhles, Hans
PY - 1998
DA - 1998/09/01
PB - Elsevier
SP - 119-126
IS - 2
VL - 714
SN - 0378-4347
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1998_Heil,
author = {Martin Heil and Frank Podebrad and Thomas Beck and Armin Mosandl and Adrian C. Sewell and Hans Böhles},
title = {Enantioselective multidimensional gas chromatography–mass spectrometry in the analysis of urinary organic acids},
journal = {Journal of Chromatography B Biomedical Sciences and Applications},
year = {1998},
volume = {714},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/S0378-4347(98)00233-3},
number = {2},
pages = {119--126},
doi = {10.1016/S0378-4347(98)00233-3}
}
Cite this
MLA
Copy
Heil, Martin, et al. “Enantioselective multidimensional gas chromatography–mass spectrometry in the analysis of urinary organic acids.” Journal of Chromatography B Biomedical Sciences and Applications, vol. 714, no. 2, Sep. 1998, pp. 119-126. https://doi.org/10.1016/S0378-4347(98)00233-3.