The quorum-sensing inhibiting effects of stilbenoids and their potential structure–activity relationship
Publication type: Journal Article
Publication date: 2015-11-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
26453007
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Stilbenoids, known an important phytoalexins in plants, were renowned for their beneficial effects on cardiovascular, neurological and hepatic systems. In the present study, quorum sensing inhibition activity of ten stilbenoids were tested using Chromobacterium violaceum CV026 as the bio-indicator strain and the structure-activity relationship was also investigated. Among them, resveratrol (1), piceatannol (2) and oxyresveratrol (3) showed potential anti-QS activities. At the sub-MIC concentrations, 1-3 demonstrated a statistically significant reduction of violacein in C. violaceum CV026 in a concentration dependent manner. Furthermore, the effects of 1-3 on QS regulated virulence factors in Pseudomonas aeruginosa PAO1 were also evaluated. Our results showed that the stilbenoids 1-3 can markedly decreased the production of pyocyanin and swarming motility of P. aeruginosa PAO1. Further transcriptome analyses showed that 1-3 suppressed the expression of QS-induced genes: lasR, lasI, rhlR and rhlI.
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57
Total citations:
57
Citations from 2025:
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(14.04%)
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GOST
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Sheng J. et al. The quorum-sensing inhibiting effects of stilbenoids and their potential structure–activity relationship // Bioorganic and Medicinal Chemistry Letters. 2015. Vol. 25. No. 22. pp. 5217-5220.
GOST all authors (up to 50)
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Sheng J., Chen T. T., TAN X., Ting Chen 陈., Jia A. The quorum-sensing inhibiting effects of stilbenoids and their potential structure–activity relationship // Bioorganic and Medicinal Chemistry Letters. 2015. Vol. 25. No. 22. pp. 5217-5220.
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RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2015.09.064
UR - https://doi.org/10.1016/j.bmcl.2015.09.064
TI - The quorum-sensing inhibiting effects of stilbenoids and their potential structure–activity relationship
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Sheng, Ji-Yang
AU - Chen, Tong Tong
AU - TAN, Xiao-juan
AU - Ting Chen, 陈挺
AU - Jia, Ai-Qun
PY - 2015
DA - 2015/11/01
PB - Elsevier
SP - 5217-5220
IS - 22
VL - 25
PMID - 26453007
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (up to 50 authors)
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@article{2015_Sheng,
author = {Ji-Yang Sheng and Tong Tong Chen and Xiao-juan TAN and 陈挺 Ting Chen and Ai-Qun Jia},
title = {The quorum-sensing inhibiting effects of stilbenoids and their potential structure–activity relationship},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2015},
volume = {25},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.bmcl.2015.09.064},
number = {22},
pages = {5217--5220},
doi = {10.1016/j.bmcl.2015.09.064}
}
Cite this
MLA
Copy
Sheng, Ji-Yang, et al. “The quorum-sensing inhibiting effects of stilbenoids and their potential structure–activity relationship.” Bioorganic and Medicinal Chemistry Letters, vol. 25, no. 22, Nov. 2015, pp. 5217-5220. https://doi.org/10.1016/j.bmcl.2015.09.064.