Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid β aggregation inhibitor
Тип публикации: Journal Article
Дата публикации: 2019-08-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
31262559
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
A structure activity relationship study of curcumin analogues for the inhibition of amyloid β aggregation is described. Optimization of the o-phenol and olefin spacer resulted in the identification of the C5-monoketone type curcumin analogue AY1319, which exhibited potent anti-amyloid β aggregation activity (leading to nanorod-like fragments), sufficient water solubility, and low cytotoxicity.
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Hotsumi M. et al. Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid β aggregation inhibitor // Bioorganic and Medicinal Chemistry Letters. 2019. Vol. 29. No. 16. pp. 2157-2161.
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Hotsumi M., Tajiri M., Nikaido Y., Sato T., Makabe K., Konno H. Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid β aggregation inhibitor // Bioorganic and Medicinal Chemistry Letters. 2019. Vol. 29. No. 16. pp. 2157-2161.
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TY - JOUR
DO - 10.1016/j.bmcl.2019.06.052
UR - https://doi.org/10.1016/j.bmcl.2019.06.052
TI - Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid β aggregation inhibitor
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Hotsumi, Mayumi
AU - Tajiri, Misato
AU - Nikaido, Yuri
AU - Sato, Taki
AU - Makabe, Koki
AU - Konno, Hiroyuki
PY - 2019
DA - 2019/08/01
PB - Elsevier
SP - 2157-2161
IS - 16
VL - 29
PMID - 31262559
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2019_Hotsumi,
author = {Mayumi Hotsumi and Misato Tajiri and Yuri Nikaido and Taki Sato and Koki Makabe and Hiroyuki Konno},
title = {Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid β aggregation inhibitor},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2019},
volume = {29},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.bmcl.2019.06.052},
number = {16},
pages = {2157--2161},
doi = {10.1016/j.bmcl.2019.06.052}
}
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MLA
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Hotsumi, Mayumi, et al. “Design, synthesis, and evaluation of a water soluble C5-monoketone type curcumin analogue as a potent amyloid β aggregation inhibitor.” Bioorganic and Medicinal Chemistry Letters, vol. 29, no. 16, Aug. 2019, pp. 2157-2161. https://doi.org/10.1016/j.bmcl.2019.06.052.