Polymer, volume 179, pages 121617
Protein-like energetics of conformational transitions in a polyampholyte hydrogel
Publication type: Journal Article
Publication date: 2019-09-01
Materials Chemistry
Organic Chemistry
Polymers and Plastics
Abstract
Abstract The volume phase transition of a hydrogel of the polyampholyte network N-isopropylacrylamide (6000) - N-(3-aminopropylmethacrylamide) (120) - Acrylic acid (120) - N,N′-Methylenebisacrylamide (40) was investigated by high-sensitivity differential scanning calorimetry in relation to pH, concentrations of NaCl and two oppositely charged drug ligands (ibuprofen and propranolol). The transition temperature, enthalpy, heat capacity increment and width against these thermodynamic variables were determined. The experimental data were used for calculation of the excess free energy functions of the phase transition which are measures of the relative stability of the dense (collapsed) state of the polyampholyte network under different conditions. By analogy with globular proteins, the stability of the network dense state is maximal at the isoelectric point of the polyampholyte and is increased by the kosmotropic salt and specific ligands. We demonstrate that the polyampholyte hydrogel consists of independent cooperative domains. The sizes of these domains in the hydrogel (9–15 kDa) are comparable with those in globular proteins.
Citations by journals
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1 publication, 9.09%
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Citations by publishers
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Elsevier
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3 publications, 27.27%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
2 publications, 18.18%
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Wiley
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Wiley
2 publications, 18.18%
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Springer Nature
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Springer Nature
1 publication, 9.09%
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IOP Publishing
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IOP Publishing
1 publication, 9.09%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 9.09%
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3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Manucha W. et al. Protein-like energetics of conformational transitions in a polyampholyte hydrogel // Polymer. 2019. Vol. 179. p. 121617.
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Manucha W., Burova T. V., Grinberg N. V., Alvarez‐Lorenzo C., Khokhlov A. R. Protein-like energetics of conformational transitions in a polyampholyte hydrogel // Polymer. 2019. Vol. 179. p. 121617.
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TY - JOUR
DO - 10.1016/j.polymer.2019.121617
UR - https://doi.org/10.1016%2Fj.polymer.2019.121617
TI - Protein-like energetics of conformational transitions in a polyampholyte hydrogel
T2 - Polymer
AU - Manucha, Walter
AU - Burova, Tatiana V
AU - Grinberg, Natalia V
AU - Alvarez‐Lorenzo, Carmen
AU - Khokhlov, Alexei R.
PY - 2019
DA - 2019/09/01 00:00:00
PB - Elsevier
SP - 121617
VL - 179
SN - 0032-3861
ER -
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@article{2019_Manucha,
author = {Walter Manucha and Tatiana V Burova and Natalia V Grinberg and Carmen Alvarez‐Lorenzo and Alexei R. Khokhlov},
title = {Protein-like energetics of conformational transitions in a polyampholyte hydrogel},
journal = {Polymer},
year = {2019},
volume = {179},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2Fj.polymer.2019.121617},
pages = {121617},
doi = {10.1016/j.polymer.2019.121617}
}