Identification of a New Natural Vasorelaxatant Compound, (+)-Osbeckic Acid, from Rutin-free Tartary Buckwheat Extract
Publication type: Journal Article
Publication date: 2010-09-28
scimago Q1
wos Q1
SJR: 1.215
CiteScore: 9.3
Impact factor: 6.2
ISSN: 00218561, 15205118
PubMed ID:
20873790
General Chemistry
General Agricultural and Biological Sciences
Abstract
The candidates responsible for vasorelaxation action of rutin-free tartary buckwheat extract (TBSP) were examined in this study. As a result of reversed-phase high-performance liquid chromatography (HPLC) separations, five prominent peaks in the acidic fraction of TBSP were obtained at 260 nm. Among the five collected peaks, we successfully identified four compounds by nuclear magnetic resonance (NMR) and mass spectrometry (MS) measurements: (+)-osbeckic acid as a dimer ([M - H](-) m/z: 371.2 > 184.9 > 140.9), 5-hydroxymethyl-2-furoic acid, protocatechuic acid, and p-hydroxybenzoic acid. A vascular contractive measurement in 1.0 μM phenylephrine-contracted Sprague-Dawley rat thoracic aorta rings revealed that (+)-osbeckic acid dimer evoked a potent vasorelaxant effect with an EC50 value of 887 μM compared to other isolates (EC50: 5-hydroxymethyl-2-furoic acid, 3610 μM; protocatechuic acid, 2160 μM; p-hydroxybenzoic acid, no inhibition). Dimeric (+)-osbeckic acid was stable in solutions and at high temperatures, while its degraded peak on the HPLC chromatogram was observed when it was dissolved in dimethyl sulfoxide.
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GOST
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MATSUI T. et al. Identification of a New Natural Vasorelaxatant Compound, (+)-Osbeckic Acid, from Rutin-free Tartary Buckwheat Extract // Journal of Agricultural and Food Chemistry. 2010. Vol. 58. No. 20. pp. 10876-10879.
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MATSUI T., Kudo A., Tokuda S., Matsumoto K., HOSOYAMA H. Identification of a New Natural Vasorelaxatant Compound, (+)-Osbeckic Acid, from Rutin-free Tartary Buckwheat Extract // Journal of Agricultural and Food Chemistry. 2010. Vol. 58. No. 20. pp. 10876-10879.
Cite this
RIS
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TY - JOUR
DO - 10.1021/jf1028416
UR - https://doi.org/10.1021/jf1028416
TI - Identification of a New Natural Vasorelaxatant Compound, (+)-Osbeckic Acid, from Rutin-free Tartary Buckwheat Extract
T2 - Journal of Agricultural and Food Chemistry
AU - MATSUI, Toshiro
AU - Kudo, Akihiro
AU - Tokuda, Shinji
AU - Matsumoto, Kiyoshi
AU - HOSOYAMA, Hirokazu
PY - 2010
DA - 2010/09/28
PB - American Chemical Society (ACS)
SP - 10876-10879
IS - 20
VL - 58
PMID - 20873790
SN - 0021-8561
SN - 1520-5118
ER -
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BibTex (up to 50 authors)
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@article{2010_MATSUI,
author = {Toshiro MATSUI and Akihiro Kudo and Shinji Tokuda and Kiyoshi Matsumoto and Hirokazu HOSOYAMA},
title = {Identification of a New Natural Vasorelaxatant Compound, (+)-Osbeckic Acid, from Rutin-free Tartary Buckwheat Extract},
journal = {Journal of Agricultural and Food Chemistry},
year = {2010},
volume = {58},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/jf1028416},
number = {20},
pages = {10876--10879},
doi = {10.1021/jf1028416}
}
Cite this
MLA
Copy
MATSUI, Toshiro, et al. “Identification of a New Natural Vasorelaxatant Compound, (+)-Osbeckic Acid, from Rutin-free Tartary Buckwheat Extract.” Journal of Agricultural and Food Chemistry, vol. 58, no. 20, Sep. 2010, pp. 10876-10879. https://doi.org/10.1021/jf1028416.