Journal of Natural Products

, volume 66 , issue 12 , pages 1582-1585

Lucidenic Acids P and Q, Methyl Lucidenate P, and Other Triterpenoids from the Fungus Ganoderma lucidum and Their Inhibitory Effects on Epstein−Barr Virus Activation

Kenji Iwatsuki ¹

Toshihiro Akihisa ¹

Harukuni Tokuda ¹

Motohiko Ukiya ¹

Manabu Oshikubo ¹

Yumiko Kimura ¹

Takeshi ASANO ¹

Atsushi Nomura ¹

Hoyoku Nishino ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

K-Laboratories for Intelligent Medical Remote Services, 2266-22 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-0003, Japan, College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan, Department of Biochemistry and Department of Orthopaedics, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-0841, Japan, and College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan

Nihon University

Kyoto Prefectural University of Medicine

Publication type: Journal Article

Publication date: 2003-12-01

American Chemical Society (ACS)

Journal of Natural Products

scimago Q1

wos Q1

SJR: 0.629

CiteScore: 6.5

Impact factor: 3.6

ISSN: 01633864, 15206025

DOI: 10.1021/np0302293

Copy DOI

PubMed ID: 14695801

Organic Chemistry

Drug Discovery

Pharmacology

Pharmaceutical Science

Molecular Medicine

Complementary and alternative medicine

Analytical Chemistry

Abstract

A new triterpene acid, lucidenic acid P (1a), and two new triterpene acid methyl esters, methyl lucidenates P (1b) and Q (2b), were isolated and characterized from the fruiting body of the fungus Ganoderma lucidum. Their structures were elucidated on the basis of spectroscopic methods. In addition, eight known triterpene acids, lucidenic acids A (3a), C (4a), D(2) (5a), E(2) (6a), and F (7a) and ganoderic acids E (9a), F (10a), and T-Q (11a), and six known triterpene acid methyl esters, methyl lucidenates A (3b), D(2) (5b), E(2) (6b), F (7b), and L (8b) and methyl ganoderate F (10b), were isolated and identified from the fungus. All of the triterpenoids, with the exception of 7a, were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, which is known to be a primary screening test for antitumor promoters. All of the compounds tested showed potent inhibitory effects on EBV-EA induction (96-100% inhibition at 1 x 10(3) mol ratio/TPA).

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GOST |

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GOST Copy

Iwatsuki K. et al. Lucidenic Acids P and Q, Methyl Lucidenate P, and Other Triterpenoids from the Fungus Ganoderma lucidum and Their Inhibitory Effects on Epstein−Barr Virus Activation // Journal of Natural Products. 2003. Vol. 66. No. 12. pp. 1582-1585.

GOST all authors (up to 50) Copy

Iwatsuki K., Akihisa T., Tokuda H., Ukiya M., Oshikubo M., Kimura Y., ASANO T., Nomura A., Nishino H. Lucidenic Acids P and Q, Methyl Lucidenate P, and Other Triterpenoids from the Fungus Ganoderma lucidum and Their Inhibitory Effects on Epstein−Barr Virus Activation // Journal of Natural Products. 2003. Vol. 66. No. 12. pp. 1582-1585.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/np0302293

UR - https://doi.org/10.1021/np0302293

TI - Lucidenic Acids P and Q, Methyl Lucidenate P, and Other Triterpenoids from the Fungus Ganoderma lucidum and Their Inhibitory Effects on Epstein−Barr Virus Activation

T2 - Journal of Natural Products

AU - Iwatsuki, Kenji

AU - Akihisa, Toshihiro

AU - Tokuda, Harukuni

AU - Ukiya, Motohiko

AU - Oshikubo, Manabu

AU - Kimura, Yumiko

AU - ASANO, Takeshi

AU - Nomura, Atsushi

AU - Nishino, Hoyoku

PY - 2003

DA - 2003/12/01

PB - American Chemical Society (ACS)

SP - 1582-1585

IS - 12

VL - 66

PMID - 14695801

SN - 0163-3864

SN - 1520-6025

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2003_Iwatsuki,

author = {Kenji Iwatsuki and Toshihiro Akihisa and Harukuni Tokuda and Motohiko Ukiya and Manabu Oshikubo and Yumiko Kimura and Takeshi ASANO and Atsushi Nomura and Hoyoku Nishino},

title = {Lucidenic Acids P and Q, Methyl Lucidenate P, and Other Triterpenoids from the Fungus Ganoderma lucidum and Their Inhibitory Effects on Epstein−Barr Virus Activation},

journal = {Journal of Natural Products},

year = {2003},

volume = {66},

publisher = {American Chemical Society (ACS)},

month = {dec},

url = {https://doi.org/10.1021/np0302293},

number = {12},

pages = {1582--1585},

doi = {10.1021/np0302293}

}

MLA

Cite this

MLA Copy

Iwatsuki, Kenji, et al. “Lucidenic Acids P and Q, Methyl Lucidenate P, and Other Triterpenoids from the Fungus Ganoderma lucidum and Their Inhibitory Effects on Epstein−Barr Virus Activation.” Journal of Natural Products, vol. 66, no. 12, Dec. 2003, pp. 1582-1585. https://doi.org/10.1021/np0302293.

Publisher

American Chemical Society (ACS)

Journal

Journal of Natural Products

scimago Q1

wos Q1

SJR

0.629

CiteScore

6.5

Impact factor

3.6

ISSN

01633864 (Print)

15206025 (Electronic)