Journal of Agricultural and Food Chemistry, volume 66, issue 40, pages 10438-10446

Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status?

Isabel Gutiérrez Díaz ^{1, 2}

Tania Fernández Navarro ^{1, 2}

Nuria Salazar ^{1, 3}

Begoña Bartolomé ⁴

M. Victoria Moreno-Arribas ⁴

Patricia López ^{2, 5}

Ana Suárez ^{2, 5}

Clara G. De Los Reyes-Gavilan ^{1, 3}

Miguel Gueimonde ^{1, 3}

Sonia González ^{1, 2}

Hide authors affiliations Show authors affiliations: 5 affiliations

Group Diet, Microbiota and Health, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Avda. Roma s/n Oviedo, 33011 Asturias, Spain |

Department of Functional Biology, University of Oviedo, C/Julián Clavería s/n Oviedo, 33006 Asturias, Spain |

Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias−Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Río Linares s/n Villaviciosa, 33300 Asturias, Spain |

⁴

Institute of Food Science Research (CIAL), CSIC-UAM, CEI UAM-CSIC, c/Nicolás Cabrera 9 Madrid, 28049 Madrid, Spain |

⁵

Group Basic and Translational Research in Inflammatory Diseases, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Avda. Roma s/n Oviedo, 33011 Asturias, Spain |

Publication type: Journal Article

Publication date: 2018-09-18

American Chemical Society (ACS)

Journal: Journal of Agricultural and Food Chemistry

Quartile SCImago

Quartile WOS

Impact factor: 6.1

ISSN: 00218561, 15205118

DOI: 10.1021/acs.jafc.8b04102

Copy DOI

General Chemistry

General Agricultural and Biological Sciences

Abstract

Although most of the health effects attributed to polyphenols may be linked to their phenolic-derived metabolites, the role of the intestinal derived-phenolics in human health is still far from being well understood. We determined the profile of fecal phenolic-derived metabolites, microbiota, biomarkers of oxidative stress and inflammation, and daily intake of bioactive compounds in 71 elderly volunteers. Phenylacetic and phenylpropionic acids were the main phenolic metabolites present in feces. From them, phenylacetic acid was related with a more pro-oxidant and immune stimulated status, and both were negatively associated with fecal propionate, whereas phenylpropionic acid was directly related with the fecal concentration of acetate. Moreover, phenylacetic acid was negatively associated with the Bacteroides group and Clostridium cluster XIVa and positively with Lactobacillus. These results provide a rationale to explore the potential of fecal microbial phenolic-derived metabolites as possible biomarkers of health status in future studies focused on the elderly population.

By date By citations

Top-30

Citations by journals

	1 2
Antioxidants	Antioxidants, 2, 6.67% Antioxidants 2 publications, 6.67%
Journal of Agricultural and Food Chemistry	Journal of Agricultural and Food Chemistry, 2, 6.67% Journal of Agricultural and Food Chemistry 2 publications, 6.67%
Gut Microbes	Gut Microbes, 2, 6.67% Gut Microbes 2 publications, 6.67%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 2, 6.67% International Journal of Biological Macromolecules 2 publications, 6.67%
Cell and Bioscience	Cell and Bioscience, 1, 3.33% Cell and Bioscience 1 publication, 3.33%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 3.33% Frontiers in Bioengineering and Biotechnology 1 publication, 3.33%
Nature Reviews Gastroenterology and Hepatology	Nature Reviews Gastroenterology and Hepatology, 1, 3.33% Nature Reviews Gastroenterology and Hepatology 1 publication, 3.33%
Nature Communications	Nature Communications, 1, 3.33% Nature Communications 1 publication, 3.33%
Reviews in Endocrine and Metabolic Disorders	Reviews in Endocrine and Metabolic Disorders, 1, 3.33% Reviews in Endocrine and Metabolic Disorders 1 publication, 3.33%
Clinical Nutrition ESPEN	Clinical Nutrition ESPEN, 1, 3.33% Clinical Nutrition ESPEN 1 publication, 3.33%
Science of the Total Environment	Science of the Total Environment, 1, 3.33% Science of the Total Environment 1 publication, 3.33%
Journal of Breath Research	Journal of Breath Research, 1, 3.33% Journal of Breath Research 1 publication, 3.33%
Molecular Nutrition and Food Research	Molecular Nutrition and Food Research, 1, 3.33% Molecular Nutrition and Food Research 1 publication, 3.33%
Biomedical Chromatography	Biomedical Chromatography, 1, 3.33% Biomedical Chromatography 1 publication, 3.33%
Environmental Toxicology	Environmental Toxicology, 1, 3.33% Environmental Toxicology 1 publication, 3.33%
mSphere	mSphere, 1, 3.33% mSphere 1 publication, 3.33%
Microbiology spectrum	Microbiology spectrum, 1, 3.33% Microbiology spectrum 1 publication, 3.33%
Frontiers in Nutrition	Frontiers in Nutrition, 1, 3.33% Frontiers in Nutrition 1 publication, 3.33%
Food Research International	Food Research International, 1, 3.33% Food Research International 1 publication, 3.33%
Obshchaya Reanimatologiya	Obshchaya Reanimatologiya, 1, 3.33% Obshchaya Reanimatologiya 1 publication, 3.33%
Redox Biology	Redox Biology, 1, 3.33% Redox Biology 1 publication, 3.33%
Food Bioscience	Food Bioscience, 1, 3.33% Food Bioscience 1 publication, 3.33%
Frontiers in Microbiology	Frontiers in Microbiology, 1, 3.33% Frontiers in Microbiology 1 publication, 3.33%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 3.33% Russian Chemical Reviews 1 publication, 3.33%
Nutrients	Nutrients, 1, 3.33% Nutrients 1 publication, 3.33%
	1 2

Citations by publishers

	1 2 3 4 5 6 7
Elsevier	Elsevier, 7, 23.33% Elsevier 7 publications, 23.33%
Springer Nature	Springer Nature, 4, 13.33% Springer Nature 4 publications, 13.33%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 10% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 10%
Frontiers Media S.A.	Frontiers Media S.A., 3, 10% Frontiers Media S.A. 3 publications, 10%
Wiley	Wiley, 3, 10% Wiley 3 publications, 10%
American Society for Microbiology	American Society for Microbiology, 2, 6.67% American Society for Microbiology 2 publications, 6.67%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 6.67% American Chemical Society (ACS) 2 publications, 6.67%
Taylor & Francis	Taylor & Francis, 2, 6.67% Taylor & Francis 2 publications, 6.67%
IOP Publishing	IOP Publishing, 1, 3.33% IOP Publishing 1 publication, 3.33%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 3.33% Cold Spring Harbor Laboratory 1 publication, 3.33%
V. A. Negovsky Research Institute of General Reanimatology	V. A. Negovsky Research Institute of General Reanimatology, 1, 3.33% V. A. Negovsky Research Institute of General Reanimatology 1 publication, 3.33%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 3.33% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 3.33%
	1 2 3 4 5 6 7

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0],"codes":[0,0,0,0,0,0],"imageUrls":["","","","","",""],"datasets":[{"label":"Citations number","data":[2,4,2,8,7,7],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["6.67","13.33","6.67","26.67","23.33","23.33"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Antioxidants","Journal of Agricultural and Food Chemistry","Gut Microbes","International Journal of Biological Macromolecules","Cell and Bioscience","Frontiers in Bioengineering and Biotechnology","Nature Reviews Gastroenterology and Hepatology","Nature Communications","Reviews in Endocrine and Metabolic Disorders","Clinical Nutrition ESPEN","Science of the Total Environment","Journal of Breath Research","Molecular Nutrition and Food Research","Biomedical Chromatography","Environmental Toxicology","mSphere","Microbiology spectrum","Frontiers in Nutrition","Food Research International","Obshchaya Reanimatologiya","Redox Biology","Food Bioscience","Frontiers in Microbiology","Russian Chemical Reviews","Nutrients"],"ids":[16381,22576,14022,23035,10845,13389,13351,3231,10463,1096,2679,4240,990,1016,12066,262,17855,13807,22414,18491,5799,1959,24403,23802,3372],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/dIXgZVXZ9QdQ3x3VBZzswbdEzP8zjWjWy3CRMtLp_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[6.67,6.67,6.67,6.67,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33,3.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Springer Nature","Multidisciplinary Digital Publishing Institute (MDPI)","Frontiers Media S.A.","Wiley","American Society for Microbiology","American Chemical Society (ACS)","Taylor & Francis","IOP Publishing","Cold Spring Harbor Laboratory","V. A. Negovsky Research Institute of General Reanimatology","Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii"],"ids":[17,8,202,208,11,142,40,18,2075,6909,5301,9422],"codes":[0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/hg4jJjT8wVGtHstBCc0zk465Mg9pLx3G4odCDOqE_medium.webp","\/storage\/images\/resized\/dIXgZVXZ9QdQ3x3VBZzswbdEzP8zjWjWy3CRMtLp_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp"],"datasets":[{"label":"","data":[7,4,3,3,3,2,2,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[23.33,13.33,10,10,10,6.67,6.67,6.67,3.33,3.33,3.33,3.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2019,2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0,0,1,0],"percentage":["0","0","0","0","3.33","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,1,0,0,0,0],"percentage":["0","3.33","0","0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,0,1,2,0,0],"percentage":["0","0","3.33","6.67","0","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[1,3,1,6,6,7],"percentage":["3.33","10","3.33","20","20","23.33"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[1,0,0,0,0,0],"percentage":["3.33","0","0","0","0","0"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2019,2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0,0,0,0],"percentage":["0","0","0","0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,1,0,0,0,0],"percentage":["0","3.33","0","0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,0,1,1,2,1],"percentage":["0","0","3.33","3.33","6.67","3.33"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[1,3,1,6,4,6],"percentage":["3.33","10","3.33","20","13.33","20"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[1,0,0,1,1,0],"percentage":["3.33","0","0","3.33","3.33","0"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Gutiérrez Díaz I. et al. Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status? // Journal of Agricultural and Food Chemistry. 2018. Vol. 66. No. 40. pp. 10438-10446.

GOST all authors (up to 50) Copy

Gutiérrez Díaz I., Fernández Navarro T., Salazar N., Bartolomé B., Moreno-Arribas M. V., López P., Suárez A., De Los Reyes-Gavilan C. G., Gueimonde M., González S. Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status? // Journal of Agricultural and Food Chemistry. 2018. Vol. 66. No. 40. pp. 10438-10446.

RIS |

Cite this