Single Hydrogen Bond Donation from Flavin N5 to Proximal Asparagine Ensures FAD Reduction in DNA Photolyase
Publication type: Journal Article
Publication date: 2016-03-22
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
PubMed ID:
27002596
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
The spread of the absorbance of the stable FADH(•) radical (300-700 nm) allows CPD photolyase to highly efficiently form FADH(-), making it functional for DNA repair. In this study, FTIR spectroscopy detected a strong hydrogen bond, from FAD N5-H to the carbonyl group of the Asn378 side chain, that is modulated by the redox state of FAD. The observed characteristic frequency shifts were reproduced in quantum-mechanical models of the flavin binding site, which were then employed to elucidate redox tuning governed by Asn378. We demonstrate that enhanced hydrogen bonding of the Asn378 side chain with the FADH(•) radical increases thermodynamic stabilization of the radical state, and further ensures kinetic stabilization and accumulation of the fully reduced FADH(-) state.
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Total citations:
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Citations from 2024:
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(15%)
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GOST
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Wijaya I. M. M. et al. Single Hydrogen Bond Donation from Flavin N5 to Proximal Asparagine Ensures FAD Reduction in DNA Photolyase // Journal of the American Chemical Society. 2016. Vol. 138. No. 13. pp. 4368-4376.
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Domratcheva T., Getzoff E. D. Single Hydrogen Bond Donation from Flavin N5 to Proximal Asparagine Ensures FAD Reduction in DNA Photolyase // Journal of the American Chemical Society. 2016. Vol. 138. No. 13. pp. 4368-4376.
Cite this
RIS
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TY - JOUR
DO - 10.1021/jacs.5b10533
UR - https://doi.org/10.1021/jacs.5b10533
TI - Single Hydrogen Bond Donation from Flavin N5 to Proximal Asparagine Ensures FAD Reduction in DNA Photolyase
T2 - Journal of the American Chemical Society
AU - Domratcheva, Tatiana
AU - Getzoff, Elizabeth D.
PY - 2016
DA - 2016/03/22
PB - American Chemical Society (ACS)
SP - 4368-4376
IS - 13
VL - 138
PMID - 27002596
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex (up to 50 authors)
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@article{2016_Wijaya,
author = {Tatiana Domratcheva and Elizabeth D. Getzoff},
title = {Single Hydrogen Bond Donation from Flavin N5 to Proximal Asparagine Ensures FAD Reduction in DNA Photolyase},
journal = {Journal of the American Chemical Society},
year = {2016},
volume = {138},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/jacs.5b10533},
number = {13},
pages = {4368--4376},
doi = {10.1021/jacs.5b10533}
}
Cite this
MLA
Copy
Wijaya, I. M. Mahaputra, et al. “Single Hydrogen Bond Donation from Flavin N5 to Proximal Asparagine Ensures FAD Reduction in DNA Photolyase.” Journal of the American Chemical Society, vol. 138, no. 13, Mar. 2016, pp. 4368-4376. https://doi.org/10.1021/jacs.5b10533.
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