Open Access

Scientific Reports, volume 6, issue 1, publication number 27720

Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome

Prokhorova Irina V ¹

Akulich Kseniya A. ^{2, 3}

Makeeva Desislava S. ^{2, 3}

Osterman Ilya A. ⁴

Skvortsov Dmitry A. ⁴

Sergiev Petr V. ⁴

Dontsova Olga A. ^{2, 4}

Yusupova Gulnara ¹

Yusupov Marat M. ¹

Dmitriev Sergey E. ^{2, 5, 6}

Hide authors affiliations Show authors affiliations: 6 affiliations

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Université de Strasbourg, France |

Belozersky Institute of Physico-chemical Biology, Lomonosov Moscow State University, Russia |

School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Russia |

⁴

Department of Chemistry, Lomonosov Moscow State University, Russia |

⁵

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Russia |

⁶

Department of Biochemistry, Biological Faculty, Lomonosov Moscow State University, Russia |

Publication type: Journal Article

Publication date: 2016-06-14

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/srep27720

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PubMed ID: 27296282

Multidisciplinary

Abstract

Amicoumacin A is an antibiotic that was recently shown to target bacterial ribosomes. It affects translocation and provides an additional contact interface between the ribosomal RNA and mRNA. The binding site of amicoumacin A is formed by universally conserved nucleotides of rRNA. In this work, we showed that amicoumacin A inhibits translation in yeast and mammalian systems by affecting translation elongation. We determined the structure of the amicoumacin A complex with yeast ribosomes at a resolution of 3.1 Å. Toxicity measurement demonstrated that human cancer cell lines are more susceptible to the inhibition by this compound as compared to non-cancerous ones. This might be used as a starting point to develop amicoumacin A derivatives with clinical value.

By date By citations

Citations by journals

	1 2 3
Frontiers in Microbiology	Frontiers in Microbiology, 3, 7.89% Frontiers in Microbiology 3 publications, 7.89%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 7.89% International Journal of Molecular Sciences 3 publications, 7.89%
Biochemistry (Moscow)	Biochemistry (Moscow), 3, 7.89% Biochemistry (Moscow) 3 publications, 7.89%
Biochimie	Biochimie, 2, 5.26% Biochimie 2 publications, 5.26%
European Journal of Organic Chemistry	European Journal of Organic Chemistry, 2, 5.26% European Journal of Organic Chemistry 2 publications, 5.26%
Nature Chemical Biology	Nature Chemical Biology, 1, 2.63% Nature Chemical Biology 1 publication, 2.63%
Molecules	Molecules, 1, 2.63% Molecules 1 publication, 2.63%
Organic Letters	Organic Letters, 1, 2.63% Organic Letters 1 publication, 2.63%
Antibiotics	Antibiotics, 1, 2.63% Antibiotics 1 publication, 2.63%
Cancers	Cancers, 1, 2.63% Cancers 1 publication, 2.63%
Pharmaceutics	Pharmaceutics, 1, 2.63% Pharmaceutics 1 publication, 2.63%
Chemistry of Natural Compounds	Chemistry of Natural Compounds, 1, 2.63% Chemistry of Natural Compounds 1 publication, 2.63%
Scientific Reports	Scientific Reports, 1, 2.63% Scientific Reports 1 publication, 2.63%
Cell Chemical Biology	Cell Chemical Biology, 1, 2.63% Cell Chemical Biology 1 publication, 2.63%
Current Opinion in Green and Sustainable Chemistry	Current Opinion in Green and Sustainable Chemistry, 1, 2.63% Current Opinion in Green and Sustainable Chemistry 1 publication, 2.63%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 1, 2.63% Journal of Drug Delivery Science and Technology 1 publication, 2.63%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 1, 2.63% Biomedicine and Pharmacotherapy 1 publication, 2.63%
Molecular Cell	Molecular Cell, 1, 2.63% Molecular Cell 1 publication, 2.63%
Angewandte Chemie	Angewandte Chemie, 1, 2.63% Angewandte Chemie 1 publication, 2.63%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 1, 2.63% Angewandte Chemie - International Edition 1 publication, 2.63%
ChemMedChem	ChemMedChem, 1, 2.63% ChemMedChem 1 publication, 2.63%
Journal of Natural Products	Journal of Natural Products, 1, 2.63% Journal of Natural Products 1 publication, 2.63%
Natural Product Reports	Natural Product Reports, 1, 2.63% Natural Product Reports 1 publication, 2.63%
Organic Chemistry Frontiers	Organic Chemistry Frontiers, 1, 2.63% Organic Chemistry Frontiers 1 publication, 2.63%
Nucleic Acids Research	Nucleic Acids Research, 1, 2.63% Nucleic Acids Research 1 publication, 2.63%
Biophysics (Russian Federation)	Biophysics (Russian Federation), 1, 2.63% Biophysics (Russian Federation) 1 publication, 2.63%
Bulletin of Russian State Medical University	Bulletin of Russian State Medical University, 1, 2.63% Bulletin of Russian State Medical University 1 publication, 2.63%
Studies in Natural Products Chemistry	Studies in Natural Products Chemistry, 1, 2.63% Studies in Natural Products Chemistry 1 publication, 2.63%
Biopolymers and Cell	Biopolymers and Cell, 1, 2.63% Biopolymers and Cell 1 publication, 2.63%
	1 2 3

Citations by publishers

	1 2 3 4 5 6 7 8
Elsevier	Elsevier, 8, 21.05% Elsevier 8 publications, 21.05%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 7, 18.42% Multidisciplinary Digital Publishing Institute (MDPI) 7 publications, 18.42%
Wiley	Wiley, 5, 13.16% Wiley 5 publications, 13.16%
Pleiades Publishing	Pleiades Publishing, 4, 10.53% Pleiades Publishing 4 publications, 10.53%
Springer Nature	Springer Nature, 3, 7.89% Springer Nature 3 publications, 7.89%
Frontiers Media S.A.	Frontiers Media S.A., 3, 7.89% Frontiers Media S.A. 3 publications, 7.89%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 5.26% American Chemical Society (ACS) 2 publications, 5.26%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 5.26% Royal Society of Chemistry (RSC) 2 publications, 5.26%
Oxford University Press	Oxford University Press, 1, 2.63% Oxford University Press 1 publication, 2.63%
Pirogov Russian National Research Medical University	Pirogov Russian National Research Medical University, 1, 2.63% Pirogov Russian National Research Medical University 1 publication, 2.63%
Naukova Dumka	Naukova Dumka, 1, 2.63% Naukova Dumka 1 publication, 2.63%
	1 2 3 4 5 6 7 8

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Prokhorova I. V. et al. Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome // Scientific Reports. 2016. Vol. 6. No. 1. 27720

GOST all authors (up to 50) Copy

Prokhorova I. V., Akulich K. A., Makeeva D. S., Osterman I. A., Skvortsov D. A., Sergiev P. V., Dontsova O. A., Yusupova G., Yusupov M. M., Dmitriev S. E. Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome // Scientific Reports. 2016. Vol. 6. No. 1. 27720

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/srep27720

UR - https://doi.org/10.1038%2Fsrep27720

TI - Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome

T2 - Scientific Reports

AU - Prokhorova, Irina V

AU - Akulich, Kseniya A.

AU - Makeeva, Desislava S.

AU - Osterman, Ilya A.

AU - Skvortsov, Dmitry A.

AU - Sergiev, Petr V.

AU - Dontsova, Olga A.

AU - Yusupova, Gulnara

AU - Yusupov, Marat M.

AU - Dmitriev, Sergey E.

PY - 2016

DA - 2016/06/14 00:00:00

PB - Springer Nature

IS - 1

VL - 6

PMID - 27296282

SN - 2045-2322

ER -

BibTex

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BibTex Copy

@article{2016_Prokhorova,

author = {Irina V Prokhorova and Kseniya A. Akulich and Desislava S. Makeeva and Ilya A. Osterman and Dmitry A. Skvortsov and Petr V. Sergiev and Olga A. Dontsova and Gulnara Yusupova and Marat M. Yusupov and Sergey E. Dmitriev},

title = {Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome},

journal = {Scientific Reports},

year = {2016},

volume = {6},

publisher = {Springer Nature},

month = {jun},

url = {https://doi.org/10.1038%2Fsrep27720},

number = {1},

doi = {10.1038/srep27720}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

Labs

Laboratory of Nucleoprotein Chemistry, Department of Chemistry of Natural Compounds, Faculty of Chemistry

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