Open Access
Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome
Irina V Prokhorova
1
,
Kseniya A. Akulich
2, 3
,
Desislava S. Makeeva
2, 3
,
Ilya A. Osterman
4
,
Petr V. Sergiev
4
,
Olga A. Dontsova
2, 4
,
Gulnara Yusupova
1
,
Marat M. Yusupov
1
,
Sergey E. Dmitriev
2, 5, 6
1
Publication type: Journal Article
Publication date: 2016-06-14
scimago Q1
wos Q1
SJR: 0.874
CiteScore: 6.7
Impact factor: 3.9
ISSN: 20452322
PubMed ID:
27296282
Multidisciplinary
Abstract
Amicoumacin A is an antibiotic that was recently shown to target bacterial ribosomes. It affects translocation and provides an additional contact interface between the ribosomal RNA and mRNA. The binding site of amicoumacin A is formed by universally conserved nucleotides of rRNA. In this work, we showed that amicoumacin A inhibits translation in yeast and mammalian systems by affecting translation elongation. We determined the structure of the amicoumacin A complex with yeast ribosomes at a resolution of 3.1 Å. Toxicity measurement demonstrated that human cancer cell lines are more susceptible to the inhibition by this compound as compared to non-cancerous ones. This might be used as a starting point to develop amicoumacin A derivatives with clinical value.
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Metrics
48
Total citations:
48
Citations from 2024:
9
(18%)
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GOST
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Prokhorova I. V. et al. Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome // Scientific Reports. 2016. Vol. 6. No. 1. 27720
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Prokhorova I. V., Akulich K. A., Makeeva D. S., Osterman I. A., Skvortsov D. A., Sergiev P. V., Dontsova O. A., Yusupova G., Yusupov M. M., Dmitriev S. E. Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome // Scientific Reports. 2016. Vol. 6. No. 1. 27720
Cite this
RIS
Copy
TY - JOUR
DO - 10.1038/srep27720
UR - https://www.nature.com/articles/srep27720
TI - Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome
T2 - Scientific Reports
AU - Prokhorova, Irina V
AU - Akulich, Kseniya A.
AU - Makeeva, Desislava S.
AU - Osterman, Ilya A.
AU - Skvortsov, Dmitry A.
AU - Sergiev, Petr V.
AU - Dontsova, Olga A.
AU - Yusupova, Gulnara
AU - Yusupov, Marat M.
AU - Dmitriev, Sergey E.
PY - 2016
DA - 2016/06/14
PB - Springer Nature
IS - 1
VL - 6
PMID - 27296282
SN - 2045-2322
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Prokhorova,
author = {Irina V Prokhorova and Kseniya A. Akulich and Desislava S. Makeeva and Ilya A. Osterman and Dmitry A. Skvortsov and Petr V. Sergiev and Olga A. Dontsova and Gulnara Yusupova and Marat M. Yusupov and Sergey E. Dmitriev},
title = {Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome},
journal = {Scientific Reports},
year = {2016},
volume = {6},
publisher = {Springer Nature},
month = {jun},
url = {https://www.nature.com/articles/srep27720},
number = {1},
pages = {27720},
doi = {10.1038/srep27720}
}