Open Access

Journal of the American Heart Association

, volume 3 , issue 2

Improving Blood Pressure Control Through Pharmacist Interventions: A Meta‐Analysis of Randomized Controlled Trials

V Santschi ^{1, 2, 3}

A Chiolero ¹

April L. Colosimo ⁴

Richard Platt ⁵

Patrick Taffé ¹

M Burnier ²

B Burnand ¹

G Paradis ⁵

Hide authors affiliations Show authors affiliations: 5 affiliations

Institute of social and preventive medicine, Lausanne University Hospital, Lausanne, Switzerland |

Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland |

La Source, School of Nursing Sciences, University of Applied Sciences Western Switzerland, Lausanne, Switzerland |

⁴

McGill Library, Schulich Library of Science and Engineering, McGill University, Montreal, Quebec, Canada |

⁵

Department of Epidemiology, Biostatistics, and Occupational health, McGill University, Montreal, Quebec, Canada |

Publication type: Journal Article

Publication date: 2014-03-24

Wiley

Journal of the American Heart Association

scimago Q1

wos Q1

SJR: 2.189

CiteScore: 8.5

Impact factor: 5.3

ISSN: 20479980

DOI: 10.1161/JAHA.113.000718

Copy DOI

PubMed ID: 24721801

Cardiology and Cardiovascular Medicine

Abstract

Background

Control of blood pressure ( BP ) remains a major challenge in primary care. Innovative interventions to improve BP control are therefore needed. By updating and combining data from 2 previous systematic reviews, we assess the effect of pharmacist interventions on BP and identify potential determinants of heterogeneity.

Methods and Results

Randomized controlled trials ( RCT s) assessing the effect of pharmacist interventions on BP among outpatients with or without diabetes were identified from MEDLINE , EMBASE , CINAHL , and CENTRAL databases. Weighted mean differences in BP were estimated using random effect models. Prediction intervals ( PI ) were computed to better express uncertainties in the effect estimates. Thirty‐nine RCT s were included with 14 224 patients. Pharmacist interventions mainly included patient education, feedback to physician, and medication management. Compared with usual care, pharmacist interventions showed greater reduction in systolic BP (−7.6 mm Hg, 95% CI : −9.0 to −6.3; I ² = 67%) and diastolic BP (−3.9 mm Hg, 95% CI : −5.1 to −2.8; I ² = 83%). The 95% PI ranged from −13.9 to −1.4 mm Hg for systolic BP and from −9.9 to +2.0 mm Hg for diastolic BP . The effect tended to be larger if the intervention was led by the pharmacist and was done at least monthly.

Conclusions

Pharmacist interventions – alone or in collaboration with other healthcare professionals – improved BP management. Nevertheless, pharmacist interventions had differential effects on BP , from very large to modest or no effect; and determinants of heterogeneity could not be identified. Determining the most efficient, cost‐effective, and least time‐consuming intervention should be addressed with further research.

Found

1 citation

Carlew Anne

19 publications, 372 citations, 1 review

h-index: 7

University of Texas Southwestern Medical Center

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GOST |

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GOST Copy

Santschi V. et al. Improving Blood Pressure Control Through Pharmacist Interventions: A Meta‐Analysis of Randomized Controlled Trials // Journal of the American Heart Association. 2014. Vol. 3. No. 2.

GOST all authors (up to 50) Copy

Santschi V., Chiolero A., Colosimo A. L., Platt R., Taffé P., Burnier M., Burnand B., Paradis G. Improving Blood Pressure Control Through Pharmacist Interventions: A Meta‐Analysis of Randomized Controlled Trials // Journal of the American Heart Association. 2014. Vol. 3. No. 2.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1161/JAHA.113.000718

UR - https://doi.org/10.1161/JAHA.113.000718

TI - Improving Blood Pressure Control Through Pharmacist Interventions: A Meta‐Analysis of Randomized Controlled Trials

T2 - Journal of the American Heart Association

AU - Santschi, V

AU - Chiolero, A

AU - Colosimo, April L.

AU - Platt, Richard

AU - Taffé, Patrick

AU - Burnier, M

AU - Burnand, B

AU - Paradis, G

PY - 2014

DA - 2014/03/24

PB - Wiley

IS - 2

VL - 3

PMID - 24721801

SN - 2047-9980

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2014_Santschi,

author = {V Santschi and A Chiolero and April L. Colosimo and Richard Platt and Patrick Taffé and M Burnier and B Burnand and G Paradis},

title = {Improving Blood Pressure Control Through Pharmacist Interventions: A Meta‐Analysis of Randomized Controlled Trials},

journal = {Journal of the American Heart Association},

year = {2014},

volume = {3},

publisher = {Wiley},

month = {mar},

url = {https://doi.org/10.1161/JAHA.113.000718},

number = {2},

doi = {10.1161/JAHA.113.000718}

}

Publisher

Wiley

Journal

Journal of the American Heart Association

scimago Q1

wos Q1

SJR

2.189

CiteScore

8.5

Impact factor

5.3

ISSN

20479980 (Print, Electronic)

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