Open Access
Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
Anna E Pravednikova
1, 2
,
Sergey Y Shevchenko
1
,
Victor V Kerchev
2
,
Manana R Skhirtladze
2
,
Svetlana N Larina
2
,
Zaur M. Kachaev
1
,
Y. V. Shidlovskii
1, 2
Publication type: Journal Article
Publication date: 2020-05-25
scimago Q1
wos Q1
SJR: 1.752
CiteScore: 8.7
Impact factor: 6.4
ISSN: 10761551, 15283658
PubMed ID:
32450815
Molecular Biology
Genetics
Molecular Medicine
Genetics (clinical)
Abstract
The hereditary aspect of obesity is a major focus of modern medical genetics. The genetic background is known to determine a higher-than-average prevalence of obesity in certain regions, like Oceania. There is evidence that dysfunction of brown adipose tissue (BAT) may be a risk factor for obesity and type 2 diabetes (T2D). A significant number of studies in the field focus on the UCP family. The Ucp genes code for electron transport carriers. UCP1 (thermogenin) is the most abundant protein of the UCP superfamily and is expressed in BAT, contributing to its capability of generating heat. Single nucleotide polymorphisms (SNPs) of Ucp1–Ucp3 were recently associated with risk of cardiometabolic diseases. This review covers the main Ucp SNPs A–3826G, A–1766G, A–112C, Met229Leu, Ala64Thr (Ucp1), Ala55Val, G–866A (Ucp2), and C–55 T (Ucp3), which may be associated with the development of obesity, disturbance in lipid metabolism, T2D, and cardiovascular diseases.
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Metrics
28
Total citations:
28
Citations from 2024:
10
(35%)
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GOST
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Pravednikova A. E. et al. Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases // Molecular Medicine. 2020. Vol. 26. No. 1. 51
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Pravednikova A. E., Shevchenko S. Y., Kerchev V. V., Skhirtladze M. R., Larina S. N., Kachaev Z. M., Egorov A. D., Shidlovskii Y. V. Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases // Molecular Medicine. 2020. Vol. 26. No. 1. 51
Cite this
RIS
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TY - JOUR
DO - 10.1186/s10020-020-00180-4
UR - https://doi.org/10.1186/s10020-020-00180-4
TI - Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
T2 - Molecular Medicine
AU - Pravednikova, Anna E
AU - Shevchenko, Sergey Y
AU - Kerchev, Victor V
AU - Skhirtladze, Manana R
AU - Larina, Svetlana N
AU - Kachaev, Zaur M.
AU - Egorov, Alexander D
AU - Shidlovskii, Y. V.
PY - 2020
DA - 2020/05/25
PB - Springer Nature
IS - 1
VL - 26
PMID - 32450815
SN - 1076-1551
SN - 1528-3658
ER -
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BibTex (up to 50 authors)
Copy
@article{2020_Pravednikova,
author = {Anna E Pravednikova and Sergey Y Shevchenko and Victor V Kerchev and Manana R Skhirtladze and Svetlana N Larina and Zaur M. Kachaev and Alexander D Egorov and Y. V. Shidlovskii},
title = {Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases},
journal = {Molecular Medicine},
year = {2020},
volume = {26},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1186/s10020-020-00180-4},
number = {1},
pages = {51},
doi = {10.1186/s10020-020-00180-4}
}