Role and Mechanism of Gut Microbiota in Human Disease

Yinwei Chen ¹

Jinghua Zhou ^{2, 3}

Li Wang ^{2, 4}

Hide authors affiliations Show authors affiliations: 4 affiliations

School of Medicine, Hangzhou Normal University, China |

Institute of Aging Research, School of Medicine, Hangzhou Normal University, China |

School of Medicine, Zhejiang University, China |

⁴

Department of Evolutionary Studies of Biosystems, School of Advanced Sciences, Graduate University for Advanced Studies (SOKENDAI), Japan |

Publication type: Journal Article

Publication date: 2021-03-17

Frontiers Media S.A.

Frontiers in Cellular and Infection Microbiology

scimago Q1

wos Q1

SJR: 1.393

CiteScore: 9.0

Impact factor: 4.8

ISSN: 22352988

DOI: 10.3389/fcimb.2021.625913

Copy DOI

PubMed ID: 33816335

Microbiology (medical)

Microbiology

Infectious Diseases

Immunology

Abstract

The human gut microbiome is a huge microbial community that plays an irreplaceable role in human life. With the further development of research, the influence of intestinal flora on human diseases has been gradually excavated. Gut microbiota (GM) dysbiosis has adverse health effects on the human body that will lead to a variety of chronic diseases. The underlying mechanisms of GM on human diseases are incredibly complicated. This review focuses on the regulation and mechanism of GM on neurodegenerative diseases, cardiovascular diseases, metabolic diseases and gastrointestinal diseases, thus providing a potential target for the prevention and treatment of disease.

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Cummings Jeffrey

998 publications, 138 196 citations, 4 reviews

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