Open Access
Antioxidants, volume 9, issue 6, pages 526
LC-MS Profile, Gastrointestinal and Gut Microbiota Stability and Antioxidant Activity of Rhodiola rosea Herb Metabolites: A Comparative Study with Subterranean Organs
Publication type: Journal Article
Publication date: 2020-06-16
PubMed ID:
32560093
Biochemistry
Molecular Biology
Cell Biology
Clinical Biochemistry
Physiology
Abstract
Golden root (Rhodiola rosea L., Crassulaceae) is a famous medical plant with a one-sided history of scientific interest in the roots and rhizomes as sources of bioactive compounds, unlike the herb, which has not been studied extensively. To address this deficiency, we used high-performance liquid chromatography with diode array and electrospray triple quadrupole mass detection for comparative qualitative and quantitative analysis of the metabolic profiles of Rhodiola rosea organs before and after gastrointestinal digestion in simulated conditions together with various biochemical assays to determine antioxidant properties of the extracts and selected compounds. R. rosea organs showed 146 compounds, including galloyl O-glucosides, catechins, procyanidins, simple phenolics, phenethyl alcohol derivatives, (hydroxy)cinnamates, hydroxynitrile glucosides, monoterpene O-glucosides, and flavonol O-glycosides, most of them for the first time in the species. The organ-specific distribution of compounds found for catechins, procyanidins, and cinnamyl alcohols and glucosides was typical for underground organs and flavonoids and galloylated glucoses concentrated in the herb. Extracts from rhizomes, leaves and flowers showed high phenolic content and were effective scavengers of free radicals (2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+), O2•−, •OH) and protected β-carotene in a bleaching assay. Digestion in the gastric and intestine phase influenced the composition of R. rosea extracts negatively, affecting the content of catechins, procyanidins, and galloyl glucoses, and therefore, the antioxidativity level. After gut microbiota treatment, the antioxidant capacity of rhizome extract was lower than leaves and flowers due to the aglycone composition found in the colonic phase of digestion. Our study demonstrated that the herb of R. rosea is a rich source of metabolites with high antioxidant properties and could be a valuable plant for new bioactive products.
Citations by journals
|
1
2
3
4
5
6
7
8
9
|
|
|
Chemistry of Natural Compounds
|
Chemistry of Natural Compounds
9 publications, 21.95%
|
|
Plants
|
Plants
5 publications, 12.2%
|
|
Khimiya Rastitel'nogo Syr'ya
|
Khimiya Rastitel'nogo Syr'ya
3 publications, 7.32%
|
|
Antioxidants
|
Antioxidants
2 publications, 4.88%
|
|
Journal of the Science of Food and Agriculture
|
Journal of the Science of Food and Agriculture
2 publications, 4.88%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
2 publications, 4.88%
|
|
Pharmaceuticals
|
Pharmaceuticals
1 publication, 2.44%
|
|
Applied Sciences (Switzerland)
|
Applied Sciences (Switzerland)
1 publication, 2.44%
|
|
Nutrients
|
Nutrients
1 publication, 2.44%
|
|
Foods
|
Foods
1 publication, 2.44%
|
|
Antibiotics
|
Antibiotics
1 publication, 2.44%
|
|
Molecules
|
Molecules
1 publication, 2.44%
|
|
Frontiers in Pharmacology
|
Frontiers in Pharmacology
1 publication, 2.44%
|
|
Frontiers in Nutrition
|
Frontiers in Nutrition
1 publication, 2.44%
|
|
Horticulturae
|
Horticulturae
1 publication, 2.44%
|
|
Microchimica Acta
|
Microchimica Acta
1 publication, 2.44%
|
|
Rendiconti Lincei
|
Rendiconti Lincei
1 publication, 2.44%
|
|
Phytomedicine
|
Phytomedicine
1 publication, 2.44%
|
|
JSFA reports
|
JSFA reports
1 publication, 2.44%
|
|
Metabolites
|
Metabolites
1 publication, 2.44%
|
|
Expert Opinion on Drug Discovery
|
Expert Opinion on Drug Discovery
1 publication, 2.44%
|
|
Siberian Herald of Agricultural Science
|
Siberian Herald of Agricultural Science
1 publication, 2.44%
|
|
Frontiers in Microbiology
|
Frontiers in Microbiology
1 publication, 2.44%
|
|
Phytochemistry Reviews
|
Phytochemistry Reviews
1 publication, 2.44%
|
|
1
2
3
4
5
6
7
8
9
|
Citations by publishers
|
2
4
6
8
10
12
14
16
18
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
17 publications, 41.46%
|
|
Springer Nature
|
Springer Nature
12 publications, 29.27%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
3 publications, 7.32%
|
|
Wiley
|
Wiley
3 publications, 7.32%
|
|
Altai State University
|
Altai State University
3 publications, 7.32%
|
|
Elsevier
|
Elsevier
1 publication, 2.44%
|
|
Taylor & Francis
|
Taylor & Francis
1 publication, 2.44%
|
|
SFSCA RAS
|
SFSCA RAS
1 publication, 2.44%
|
|
2
4
6
8
10
12
14
16
18
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[2,14,15,7,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["4.88","34.15","36.59","17.07","7.32"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Chemistry of Natural Compounds","Plants","Khimiya Rastitel'nogo Syr'ya","Antioxidants","Journal of the Science of Food and Agriculture","International Journal of Molecular Sciences","Pharmaceuticals","Applied Sciences (Switzerland)","Nutrients","Foods","Antibiotics","Molecules","Frontiers in Pharmacology","Frontiers in Nutrition","Horticulturae","Microchimica Acta","Rendiconti Lincei","Phytomedicine","JSFA reports","Metabolites","Expert Opinion on Drug Discovery","Siberian Herald of Agricultural Science","Frontiers in Microbiology","Phytochemistry Reviews"],"ids":[10339,17251,6190,16381,17604,14627,1203,16650,3372,11536,1488,1770,9788,13807,17670,11314,20447,5424,29362,17024,7740,36508,24403,23671],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/1P8YWvqCaC0p051dtrKEfFUtXKE0rmTrxfjoiBLh_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/yLJ9Kk3wvOOyWOz5IWGB1m81yhlhNDNKMeimpVFt_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[9,5,3,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[21.95,12.2,7.32,4.88,4.88,4.88,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44,2.44],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","Frontiers Media S.A.","Wiley","Altai State University","Elsevier","Taylor & Francis","SFSCA RAS"],"ids":[202,8,208,11,2118,17,18,9335],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/1P8YWvqCaC0p051dtrKEfFUtXKE0rmTrxfjoiBLh_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/yLJ9Kk3wvOOyWOz5IWGB1m81yhlhNDNKMeimpVFt_medium.webp"],"datasets":[{"label":"","data":[17,12,3,3,3,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[41.46,29.27,7.32,7.32,7.32,2.44,2.44,2.44],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Olennikov D. N. et al. LC-MS Profile, Gastrointestinal and Gut Microbiota Stability and Antioxidant Activity of Rhodiola rosea Herb Metabolites: A Comparative Study with Subterranean Organs // Antioxidants. 2020. Vol. 9. No. 6. p. 526.
GOST all authors (up to 50)
Copy
Olennikov D. N., Chirikova N. K., Vasilieva A. G., Fedorov I. A. LC-MS Profile, Gastrointestinal and Gut Microbiota Stability and Antioxidant Activity of Rhodiola rosea Herb Metabolites: A Comparative Study with Subterranean Organs // Antioxidants. 2020. Vol. 9. No. 6. p. 526.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/antiox9060526
UR - https://doi.org/10.3390%2Fantiox9060526
TI - LC-MS Profile, Gastrointestinal and Gut Microbiota Stability and Antioxidant Activity of Rhodiola rosea Herb Metabolites: A Comparative Study with Subterranean Organs
T2 - Antioxidants
AU - Chirikova, Nadezhda K
AU - Vasilieva, Aina G
AU - Fedorov, Innokentii A
AU - Olennikov, Daniil Nikolaevich
PY - 2020
DA - 2020/06/16 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 526
IS - 6
VL - 9
PMID - 32560093
SN - 2076-3921
ER -
Cite this
BibTex
Copy
@article{2020_Olennikov,
author = {Nadezhda K Chirikova and Aina G Vasilieva and Innokentii A Fedorov and Daniil Nikolaevich Olennikov},
title = {LC-MS Profile, Gastrointestinal and Gut Microbiota Stability and Antioxidant Activity of Rhodiola rosea Herb Metabolites: A Comparative Study with Subterranean Organs},
journal = {Antioxidants},
year = {2020},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fantiox9060526},
number = {6},
pages = {526},
doi = {10.3390/antiox9060526}
}
Cite this
MLA
Copy
Olennikov, Daniil Nikolaevich, et al. “LC-MS Profile, Gastrointestinal and Gut Microbiota Stability and Antioxidant Activity of Rhodiola rosea Herb Metabolites: A Comparative Study with Subterranean Organs.” Antioxidants, vol. 9, no. 6, Jun. 2020, p. 526. https://doi.org/10.3390%2Fantiox9060526.
Profiles