Open Access
Antioxidants, volume 9, issue 8, pages 695
Flavonoids with Glutathione Antioxidant Synergy: Influence of Free Radicals Inflow
Ilyasov Igor
1
,
Beloborodov Vladimir
1
,
Antonov Daniil
1
,
Dubrovskaya Anna
1
,
Terekhov Roman
1
,
Zhevlakova Anastasiya
1
,
Saydasheva Asiya
1
,
Evteev Vladimir
2
,
2
Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products” of the Ministry of Health of the Russian Federation, Petrovsky blvd. 8/2, 127051 Moscow, Russia
|
Publication type: Journal Article
Publication date: 2020-08-03
PubMed ID:
32756351
Biochemistry
Molecular Biology
Cell Biology
Clinical Biochemistry
Physiology
Abstract
This report explores the antioxidant interaction of combinations of flavonoid–glutathione with different ratios. Two different 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid radical (ABTS•+)-based approaches were applied for the elucidation of the antioxidant capacity of the combinations. Despite using the same radical, the two approaches employ different free radical inflow systems: An instant, great excess of radicals in the end-point decolorization assay, and a steady inflow of radicals in the lag-time assay. As expected, the flavonoid–glutathione pairs showed contrasting results in these two approaches. All the examined combinations showed additive or light subadditive antioxidant capacity effects in the decolorization assay. This effect showed slight dilution dependence and did not change when the initial ABTS•+ concentration was two times as high or low. However, in the lag-time assay, different types of interaction were detected, from subadditivity to considerable synergy. Taxifolin–glutathione combinations demonstrated the greatest synergy, at up to 112%; quercetin and rutin, in combination with glutathione, revealed moderate synergy in the 30–70% range; while morin–glutathione appeared to be additive or subadditive. In general, this study demonstrated that, on the one hand, the effect of flavonoid–glutathione combinations depends both on the flavonoid structure and molar ratio; on the other hand, the manifestation of the synergy of the combination strongly depends on the mode of inflow of the free radicals.
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2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Ilyasov I. et al. Flavonoids with Glutathione Antioxidant Synergy: Influence of Free Radicals Inflow // Antioxidants. 2020. Vol. 9. No. 8. p. 695.
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Ilyasov I., Beloborodov V., Antonov D., Dubrovskaya A., Terekhov R., Zhevlakova A., Saydasheva A., Evteev V., Selivanova I. Flavonoids with Glutathione Antioxidant Synergy: Influence of Free Radicals Inflow // Antioxidants. 2020. Vol. 9. No. 8. p. 695.
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TY - JOUR
DO - 10.3390/antiox9080695
UR - https://doi.org/10.3390%2Fantiox9080695
TI - Flavonoids with Glutathione Antioxidant Synergy: Influence of Free Radicals Inflow
T2 - Antioxidants
AU - Beloborodov, Vladimir
AU - Antonov, Daniil
AU - Dubrovskaya, Anna
AU - Terekhov, Roman
AU - Zhevlakova, Anastasiya
AU - Saydasheva, Asiya
AU - Selivanova, Irina
AU - Ilyasov, Igor
AU - Evteev, Vladimir
PY - 2020
DA - 2020/08/03 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 695
IS - 8
VL - 9
PMID - 32756351
SN - 2076-3921
ER -
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@article{2020_Ilyasov,
author = {Vladimir Beloborodov and Daniil Antonov and Anna Dubrovskaya and Roman Terekhov and Anastasiya Zhevlakova and Asiya Saydasheva and Irina Selivanova and Igor Ilyasov and Vladimir Evteev},
title = {Flavonoids with Glutathione Antioxidant Synergy: Influence of Free Radicals Inflow},
journal = {Antioxidants},
year = {2020},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {aug},
url = {https://doi.org/10.3390%2Fantiox9080695},
number = {8},
pages = {695},
doi = {10.3390/antiox9080695}
}
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Ilyasov, Igor, et al. “Flavonoids with Glutathione Antioxidant Synergy: Influence of Free Radicals Inflow.” Antioxidants, vol. 9, no. 8, Aug. 2020, p. 695. https://doi.org/10.3390%2Fantiox9080695.