Open Access
International Journal of Molecular Sciences, volume 23, issue 21, pages 13428
Molecular Mechanisms of Inhibition of Protein Amyloid Fibril Formation: Evidence and Perspectives Based on Kinetic Models
Sedov Igor A.
1, 2, 3
,
Khaibrakhmanova Diliara
1
2
Publication type: Journal Article
Publication date: 2022-11-03
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
36362217
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Inhibition of fibril formation is considered a possible treatment strategy for amyloid-related diseases. Understanding the molecular nature of inhibitor action is crucial for the design of drug candidates. In the present review, we describe the common kinetic models of fibril formation and classify known inhibitors by the mechanism of their interactions with the aggregating protein and its oligomers. This mechanism determines the step or steps of the aggregation process that become inhibited and the observed changes in kinetics and equilibrium of fibril formation. The results of numerous studies indicate that possible approaches to antiamyloid inhibitor discovery include the search for the strong binders of protein monomers, cappers blocking the ends of the growing fibril, or the species absorbing on the surface of oligomers preventing nucleation. Strongly binding inhibitors stabilizing the native state can be promising for the structured proteins while designing the drug candidates targeting disordered proteins is challenging.
Citations by journals
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1
2
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 22.22%
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Scientific Reports
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Scientific Reports
2 publications, 22.22%
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Pharmaceutics
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Pharmaceutics
1 publication, 11.11%
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Journal of Biomolecular Structure and Dynamics
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Journal of Biomolecular Structure and Dynamics
1 publication, 11.11%
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Current Opinion in Chemical Biology
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Current Opinion in Chemical Biology
1 publication, 11.11%
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Critical Reviews in Food Science and Nutrition
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Critical Reviews in Food Science and Nutrition
1 publication, 11.11%
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Journal of Chemical Physics
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Journal of Chemical Physics
1 publication, 11.11%
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1
2
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Citations by publishers
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1
2
3
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 33.33%
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Springer Nature
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Springer Nature
2 publications, 22.22%
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Taylor & Francis
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Taylor & Francis
2 publications, 22.22%
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Elsevier
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Elsevier
1 publication, 11.11%
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American Institute of Physics (AIP)
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American Institute of Physics (AIP)
1 publication, 11.11%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Sedov I. A. et al. Molecular Mechanisms of Inhibition of Protein Amyloid Fibril Formation: Evidence and Perspectives Based on Kinetic Models // International Journal of Molecular Sciences. 2022. Vol. 23. No. 21. p. 13428.
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Sedov I. A., Khaibrakhmanova D. Molecular Mechanisms of Inhibition of Protein Amyloid Fibril Formation: Evidence and Perspectives Based on Kinetic Models // International Journal of Molecular Sciences. 2022. Vol. 23. No. 21. p. 13428.
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TY - JOUR
DO - 10.3390/ijms232113428
UR - https://doi.org/10.3390%2Fijms232113428
TI - Molecular Mechanisms of Inhibition of Protein Amyloid Fibril Formation: Evidence and Perspectives Based on Kinetic Models
T2 - International Journal of Molecular Sciences
AU - Sedov, Igor A.
AU - Khaibrakhmanova, Diliara
PY - 2022
DA - 2022/11/03 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 13428
IS - 21
VL - 23
PMID - 36362217
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2022_Sedov,
author = {Igor A. Sedov and Diliara Khaibrakhmanova},
title = {Molecular Mechanisms of Inhibition of Protein Amyloid Fibril Formation: Evidence and Perspectives Based on Kinetic Models},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2Fijms232113428},
number = {21},
pages = {13428},
doi = {10.3390/ijms232113428}
}
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Sedov, Igor A., et al. “Molecular Mechanisms of Inhibition of Protein Amyloid Fibril Formation: Evidence and Perspectives Based on Kinetic Models.” International Journal of Molecular Sciences, vol. 23, no. 21, Nov. 2022, p. 13428. https://doi.org/10.3390%2Fijms232113428.
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