Open Access
Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action
Ilya Lyagin
1, 2
,
E. N. Efremenko
1, 2
Publication type: Journal Article
Publication date: 2019-06-26
PubMed ID:
31247992
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Mycotoxins are highly dangerous natural compounds produced by various fungi. Enzymatic transformation seems to be the most promising method for detoxification of mycotoxins. This review summarizes current information on enzymes of different classes to convert various mycotoxins. An in-depth analysis of 11 key enzyme mechanisms towards dozens of major mycotoxins was realized. Additionally, molecular docking of mycotoxins to enzymes’ active centers was carried out to clarify some of these catalytic mechanisms. Analyzing protein homologues from various organisms (plants, animals, fungi, and bacteria), the prevalence and availability of natural sources of active biocatalysts with a high practical potential is discussed. The importance of multifunctional enzyme combinations for detoxification of mycotoxins is posed.
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115
Total citations:
115
Citations from 2024:
39
(34%)
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GOST
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Lyagin I. et al. Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action // Molecules. 2019. Vol. 24. No. 13. p. 2362.
GOST all authors (up to 50)
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Lyagin I., Efremenko E. N. Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action // Molecules. 2019. Vol. 24. No. 13. p. 2362.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/molecules24132362
UR - https://doi.org/10.3390/molecules24132362
TI - Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action
T2 - Molecules
AU - Lyagin, Ilya
AU - Efremenko, E. N.
PY - 2019
DA - 2019/06/26
PB - MDPI
SP - 2362
IS - 13
VL - 24
PMID - 31247992
SN - 1420-3049
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Lyagin,
author = {Ilya Lyagin and E. N. Efremenko},
title = {Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action},
journal = {Molecules},
year = {2019},
volume = {24},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/molecules24132362},
number = {13},
pages = {2362},
doi = {10.3390/molecules24132362}
}
Cite this
MLA
Copy
Lyagin, Ilya, et al. “Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action.” Molecules, vol. 24, no. 13, Jun. 2019, p. 2362. https://doi.org/10.3390/molecules24132362.
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