Open Access
Natural Antioxidant Evaluation: A Review of Detection Methods
Jenifer Da Silva Mendonça
1
,
Rita de Cássia Avellaneda Guimarães
1
,
Verônica Assalin Zorgetto Pinheiro
1
,
Carolina Di Pietro Fernandes
2
,
Gabriela Marcelino
1
,
Danielle Bogo
1
,
Karine de Cássia Freitas
1
,
Priscila Aiko Hiane
1
,
Elaine Silva De Pádua Melo
1, 2, 3
,
Marcelo Luiz Brandão Vilela
3
,
Valter Aragão Do Nascimento
1, 2, 3
Publication type: Journal Article
Publication date: 2022-06-01
PubMed ID:
35684500
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Antioxidants have drawn the attention of the scientific community due to being related to the prevention of various degenerative diseases. The antioxidant capacity has been extensively studied in vitro, and different methods have been used to assess its activity. However, the main issues related to studying natural antioxidants are evaluating whether these antioxidants demonstrate a key role in the biological system and assessing their bioavailability in the organism. The majority of outcomes in the literature are controversial due to a lack of method standardization and their proper application. Therefore, this study aims to compile the main issues concerning the natural antioxidant field of study, comparing the most common in vitro methods to evaluate the antioxidant activity of natural compounds, demonstrating the antioxidant activity in biological systems and the role of the main antioxidant enzymes of redox cellular signaling and explaining how the bioavailability of bioactive compounds is evaluated in animal models and human clinical trials.
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99
Total citations:
99
Citations from 2025:
46
(46.46%)
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MLA
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GOST
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Mendonça J. D. S. et al. Natural Antioxidant Evaluation: A Review of Detection Methods // Molecules. 2022. Vol. 27. No. 11. p. 3563.
GOST all authors (up to 50)
Copy
Mendonça J. D. S., Guimarães R. D. C. A., Zorgetto Pinheiro V. A., Fernandes C. D. P., Marcelino G., Bogo D., Freitas K. D. C., Hiane P. A., De Pádua Melo E. S., Vilela M. L. B., Aragão Do Nascimento V. Natural Antioxidant Evaluation: A Review of Detection Methods // Molecules. 2022. Vol. 27. No. 11. p. 3563.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/molecules27113563
UR - https://doi.org/10.3390/molecules27113563
TI - Natural Antioxidant Evaluation: A Review of Detection Methods
T2 - Molecules
AU - Mendonça, Jenifer Da Silva
AU - Guimarães, Rita de Cássia Avellaneda
AU - Zorgetto Pinheiro, Verônica Assalin
AU - Fernandes, Carolina Di Pietro
AU - Marcelino, Gabriela
AU - Bogo, Danielle
AU - Freitas, Karine de Cássia
AU - Hiane, Priscila Aiko
AU - De Pádua Melo, Elaine Silva
AU - Vilela, Marcelo Luiz Brandão
AU - Aragão Do Nascimento, Valter
PY - 2022
DA - 2022/06/01
PB - MDPI
SP - 3563
IS - 11
VL - 27
PMID - 35684500
SN - 1420-3049
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Mendonça,
author = {Jenifer Da Silva Mendonça and Rita de Cássia Avellaneda Guimarães and Verônica Assalin Zorgetto Pinheiro and Carolina Di Pietro Fernandes and Gabriela Marcelino and Danielle Bogo and Karine de Cássia Freitas and Priscila Aiko Hiane and Elaine Silva De Pádua Melo and Marcelo Luiz Brandão Vilela and Valter Aragão Do Nascimento},
title = {Natural Antioxidant Evaluation: A Review of Detection Methods},
journal = {Molecules},
year = {2022},
volume = {27},
publisher = {MDPI},
month = {jun},
url = {https://doi.org/10.3390/molecules27113563},
number = {11},
pages = {3563},
doi = {10.3390/molecules27113563}
}
Cite this
MLA
Copy
Mendonça, Jenifer Da Silva, et al. “Natural Antioxidant Evaluation: A Review of Detection Methods.” Molecules, vol. 27, no. 11, Jun. 2022, p. 3563. https://doi.org/10.3390/molecules27113563.