Advances in Enzyme Research

Scientific Research Publishing

ISSN: 23284846, 23284854

Публикации журнала в Cobalt

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Годы выпуска

2025

Варианты названий

Advances in Enzyme Research

за всё время с 2021

Публикаций

Цитирований

769

Индекс Хирша

Публикаций

Цитирований

472

Топ-3 цитирующих журналов

International Journal of Biological Macromolecules (17 цитирований)

Biocatalysis and Agricultural Biotechnology (16 цитирований)

Advances in Enzyme Research (15 цитирований)

Наиболее цитируемые за 5 лет

Название публикации

Топ-100

Цитирующие журналы

	2 4 6 8 10 12 14 16 18
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 17, 2.21% International Journal of Biological Macromolecules 17 цитирований, 2.21%
Biocatalysis and Agricultural Biotechnology	Biocatalysis and Agricultural Biotechnology, 16, 2.08% Biocatalysis and Agricultural Biotechnology 16 цитирований, 2.08%
Advances in Enzyme Research	Advances in Enzyme Research, 15, 1.95% Advances in Enzyme Research 15 цитирований, 1.95%
3 Biotech	3 Biotech, 11, 1.43% 3 Biotech 11 цитирований, 1.43%
Scientific Reports	Scientific Reports, 8, 1.04% Scientific Reports 8 цитирований, 1.04%
Fermentation	Fermentation, 8, 1.04% Fermentation 8 цитирований, 1.04%
Preparative Biochemistry and Biotechnology	Preparative Biochemistry and Biotechnology, 8, 1.04% Preparative Biochemistry and Biotechnology 8 цитирований, 1.04%
Applied Biochemistry and Biotechnology	Applied Biochemistry and Biotechnology, 7, 0.91% Applied Biochemistry and Biotechnology 7 цитирований, 0.91%
Frontiers in Microbiology	Frontiers in Microbiology, 7, 0.91% Frontiers in Microbiology 7 цитирований, 0.91%
Biomass Conversion and Biorefinery	Biomass Conversion and Biorefinery, 6, 0.78% Biomass Conversion and Biorefinery 6 цитирований, 0.78%
IOP Conference Series: Earth and Environmental Science	IOP Conference Series: Earth and Environmental Science, 6, 0.78% IOP Conference Series: Earth and Environmental Science 6 цитирований, 0.78%
Fungal Biology	Fungal Biology, 6, 0.78% Fungal Biology 6 цитирований, 0.78%
Brazilian Journal of Microbiology	Brazilian Journal of Microbiology, 6, 0.78% Brazilian Journal of Microbiology 6 цитирований, 0.78%
Anais da Academia Brasileira de Ciencias	Anais da Academia Brasileira de Ciencias, 5, 0.65% Anais da Academia Brasileira de Ciencias 5 цитирований, 0.65%
Biocatalysis and Biotransformation	Biocatalysis and Biotransformation, 5, 0.65% Biocatalysis and Biotransformation 5 цитирований, 0.65%
PLoS ONE	PLoS ONE, 5, 0.65% PLoS ONE 5 цитирований, 0.65%
PeerJ	PeerJ, 4, 0.52% PeerJ 4 цитирования, 0.52%
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993)	Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 4, 0.52% Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 4 цитирования, 0.52%
Applied Soil Ecology	Applied Soil Ecology, 4, 0.52% Applied Soil Ecology 4 цитирования, 0.52%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 4, 0.52% International Journal of Molecular Sciences 4 цитирования, 0.52%
Process Biochemistry	Process Biochemistry, 4, 0.52% Process Biochemistry 4 цитирования, 0.52%
Waste and Biomass Valorization	Waste and Biomass Valorization, 4, 0.52% Waste and Biomass Valorization 4 цитирования, 0.52%
Environmental Monitoring and Assessment	Environmental Monitoring and Assessment, 4, 0.52% Environmental Monitoring and Assessment 4 цитирования, 0.52%
Journal of Genetic Engineering and Biotechnology	Journal of Genetic Engineering and Biotechnology, 4, 0.52% Journal of Genetic Engineering and Biotechnology 4 цитирования, 0.52%
bioRxiv	bioRxiv, 4, 0.52% bioRxiv 4 цитирования, 0.52%
Molecules	Molecules, 3, 0.39% Molecules 3 цитирования, 0.39%
Science of the Total Environment	Science of the Total Environment, 3, 0.39% Science of the Total Environment 3 цитирования, 0.39%
Catalysis Letters	Catalysis Letters, 3, 0.39% Catalysis Letters 3 цитирования, 0.39%
Catalysts	Catalysts, 3, 0.39% Catalysts 3 цитирования, 0.39%
Bioresource Technology	Bioresource Technology, 3, 0.39% Bioresource Technology 3 цитирования, 0.39%
Microorganisms	Microorganisms, 3, 0.39% Microorganisms 3 цитирования, 0.39%
Agronomy	Agronomy, 3, 0.39% Agronomy 3 цитирования, 0.39%
Molecular Biotechnology	Molecular Biotechnology, 3, 0.39% Molecular Biotechnology 3 цитирования, 0.39%
International Biodeterioration and Biodegradation	International Biodeterioration and Biodegradation, 3, 0.39% International Biodeterioration and Biodegradation 3 цитирования, 0.39%
Pest Management Science	Pest Management Science, 3, 0.39% Pest Management Science 3 цитирования, 0.39%
Environmental Pollution	Environmental Pollution, 3, 0.39% Environmental Pollution 3 цитирования, 0.39%
Plant Physiology and Biochemistry	Plant Physiology and Biochemistry, 3, 0.39% Plant Physiology and Biochemistry 3 цитирования, 0.39%
Bioprocess and Biosystems Engineering	Bioprocess and Biosystems Engineering, 3, 0.39% Bioprocess and Biosystems Engineering 3 цитирования, 0.39%
Plants	Plants, 3, 0.39% Plants 3 цитирования, 0.39%
Sustainability	Sustainability, 3, 0.39% Sustainability 3 цитирования, 0.39%
Biotechnology Advances	Biotechnology Advances, 3, 0.39% Biotechnology Advances 3 цитирования, 0.39%
Applied Microbiology and Biotechnology	Applied Microbiology and Biotechnology, 3, 0.39% Applied Microbiology and Biotechnology 3 цитирования, 0.39%
Environmental Technology and Innovation	Environmental Technology and Innovation, 3, 0.39% Environmental Technology and Innovation 3 цитирования, 0.39%
Heliyon	Heliyon, 3, 0.39% Heliyon 3 цитирования, 0.39%
World Journal of Microbiology and Biotechnology	World Journal of Microbiology and Biotechnology, 3, 0.39% World Journal of Microbiology and Biotechnology 3 цитирования, 0.39%
Chemosphere	Chemosphere, 3, 0.39% Chemosphere 3 цитирования, 0.39%
Environmental Science and Pollution Research	Environmental Science and Pollution Research, 3, 0.39% Environmental Science and Pollution Research 3 цитирования, 0.39%
Journal of Economic Entomology	Journal of Economic Entomology, 2, 0.26% Journal of Economic Entomology 2 цитирования, 0.26%
Food Bioscience	Food Bioscience, 2, 0.26% Food Bioscience 2 цитирования, 0.26%
Molecular Genetics and Genomics	Molecular Genetics and Genomics, 2, 0.26% Molecular Genetics and Genomics 2 цитирования, 0.26%
Enzyme Research	Enzyme Research, 2, 0.26% Enzyme Research 2 цитирования, 0.26%
Environmental Research	Environmental Research, 2, 0.26% Environmental Research 2 цитирования, 0.26%
Biotechnology and Applied Biochemistry	Biotechnology and Applied Biochemistry, 2, 0.26% Biotechnology and Applied Biochemistry 2 цитирования, 0.26%
Animals	Animals, 2, 0.26% Animals 2 цитирования, 0.26%
Genes	Genes, 2, 0.26% Genes 2 цитирования, 0.26%
Pedosphere	Pedosphere, 2, 0.26% Pedosphere 2 цитирования, 0.26%
Journal of Molecular Structure	Journal of Molecular Structure, 2, 0.26% Journal of Molecular Structure 2 цитирования, 0.26%
Journal of Invertebrate Pathology	Journal of Invertebrate Pathology, 2, 0.26% Journal of Invertebrate Pathology 2 цитирования, 0.26%
ChemCatChem	ChemCatChem, 2, 0.26% ChemCatChem 2 цитирования, 0.26%
International Journal of Peptide Research and Therapeutics	International Journal of Peptide Research and Therapeutics, 2, 0.26% International Journal of Peptide Research and Therapeutics 2 цитирования, 0.26%
Soil Biology and Biochemistry	Soil Biology and Biochemistry, 2, 0.26% Soil Biology and Biochemistry 2 цитирования, 0.26%
Protein and Peptide Letters	Protein and Peptide Letters, 2, 0.26% Protein and Peptide Letters 2 цитирования, 0.26%
Applied Biochemistry and Microbiology	Applied Biochemistry and Microbiology, 2, 0.26% Applied Biochemistry and Microbiology 2 цитирования, 0.26%
Journal of Molecular Liquids	Journal of Molecular Liquids, 2, 0.26% Journal of Molecular Liquids 2 цитирования, 0.26%
Biotechnology Progress	Biotechnology Progress, 2, 0.26% Biotechnology Progress 2 цитирования, 0.26%
Extremophiles	Extremophiles, 2, 0.26% Extremophiles 2 цитирования, 0.26%
Applied and Environmental Microbiology	Applied and Environmental Microbiology, 2, 0.26% Applied and Environmental Microbiology 2 цитирования, 0.26%
Chemico-Biological Interactions	Chemico-Biological Interactions, 2, 0.26% Chemico-Biological Interactions 2 цитирования, 0.26%
Chemistry and Ecology	Chemistry and Ecology, 2, 0.26% Chemistry and Ecology 2 цитирования, 0.26%
Journal of Basic Microbiology	Journal of Basic Microbiology, 2, 0.26% Journal of Basic Microbiology 2 цитирования, 0.26%
Applied Sciences (Switzerland)	Applied Sciences (Switzerland), 2, 0.26% Applied Sciences (Switzerland) 2 цитирования, 0.26%
Biomass and Bioenergy	Biomass and Bioenergy, 2, 0.26% Biomass and Bioenergy 2 цитирования, 0.26%
Journal of King Saud University - Science	Journal of King Saud University - Science, 2, 0.26% Journal of King Saud University - Science 2 цитирования, 0.26%
Bioresources and Bioprocessing	Bioresources and Bioprocessing, 2, 0.26% Bioresources and Bioprocessing 2 цитирования, 0.26%
ACS Omega	ACS Omega, 2, 0.26% ACS Omega 2 цитирования, 0.26%
Electronic Journal of Biotechnology	Electronic Journal of Biotechnology, 2, 0.26% Electronic Journal of Biotechnology 2 цитирования, 0.26%
Frontiers in Environmental Science	Frontiers in Environmental Science, 2, 0.26% Frontiers in Environmental Science 2 цитирования, 0.26%
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2, 0.26% Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2 цитирования, 0.26%
AIP Conference Proceedings	AIP Conference Proceedings, 2, 0.26% AIP Conference Proceedings 2 цитирования, 0.26%
Journal of Bacteriology	Journal of Bacteriology, 2, 0.26% Journal of Bacteriology 2 цитирования, 0.26%
Southwestern Entomologist	Southwestern Entomologist, 2, 0.26% Southwestern Entomologist 2 цитирования, 0.26%
Journal of Bioscience and Bioengineering	Journal of Bioscience and Bioengineering, 2, 0.26% Journal of Bioscience and Bioengineering 2 цитирования, 0.26%
Journal of Electroanalytical Chemistry	Journal of Electroanalytical Chemistry, 2, 0.26% Journal of Electroanalytical Chemistry 2 цитирования, 0.26%
Journal of Agricultural and Food Chemistry	Journal of Agricultural and Food Chemistry, 2, 0.26% Journal of Agricultural and Food Chemistry 2 цитирования, 0.26%
Food and Bioproducts Processing	Food and Bioproducts Processing, 2, 0.26% Food and Bioproducts Processing 2 цитирования, 0.26%
Annals of Microbiology	Annals of Microbiology, 2, 0.26% Annals of Microbiology 2 цитирования, 0.26%
Energies	Energies, 2, 0.26% Energies 2 цитирования, 0.26%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 2, 0.26% Biomedicine and Pharmacotherapy 2 цитирования, 0.26%
Biology	Biology, 2, 0.26% Biology 2 цитирования, 0.26%
Materials Today: Proceedings	Materials Today: Proceedings, 2, 0.26% Materials Today: Proceedings 2 цитирования, 0.26%
Energy, Ecology and Environment	Energy, Ecology and Environment, 2, 0.26% Energy, Ecology and Environment 2 цитирования, 0.26%
Brazilian Archives of Biology and Technology	Brazilian Archives of Biology and Technology, 2, 0.26% Brazilian Archives of Biology and Technology 2 цитирования, 0.26%
Journal of Proteins and Proteomics	Journal of Proteins and Proteomics, 2, 0.26% Journal of Proteins and Proteomics 2 цитирования, 0.26%
Systems Microbiology and Biomanufacturing	Systems Microbiology and Biomanufacturing, 2, 0.26% Systems Microbiology and Biomanufacturing 2 цитирования, 0.26%
Cleaner Materials	Cleaner Materials, 2, 0.26% Cleaner Materials 2 цитирования, 0.26%
Environmental and Microbial Biotechnology	Environmental and Microbial Biotechnology, 2, 0.26% Environmental and Microbial Biotechnology 2 цитирования, 0.26%
Advances in Geographical and Environmental Sciences	Advances in Geographical and Environmental Sciences, 2, 0.26% Advances in Geographical and Environmental Sciences 2 цитирования, 0.26%
Reproduction in Domestic Animals	Reproduction in Domestic Animals, 1, 0.13% Reproduction in Domestic Animals 1 цитирование, 0.13%
Korean Journal of Chemical Engineering	Korean Journal of Chemical Engineering, 1, 0.13% Korean Journal of Chemical Engineering 1 цитирование, 0.13%
Electrochemistry Communications	Electrochemistry Communications, 1, 0.13% Electrochemistry Communications 1 цитирование, 0.13%

	2 4 6 8 10 12 14 16 18

Цитирующие издатели

	50 100 150 200 250
Elsevier	Elsevier, 228, 29.65% Elsevier 228 цитирований, 29.65%
Springer Nature	Springer Nature, 166, 21.59% Springer Nature 166 цитирований, 21.59%
MDPI	MDPI, 67, 8.71% MDPI 67 цитирований, 8.71%
Wiley	Wiley, 61, 7.93% Wiley 61 цитирование, 7.93%
Taylor & Francis	Taylor & Francis, 34, 4.42% Taylor & Francis 34 цитирования, 4.42%
Scientific Research Publishing	Scientific Research Publishing, 17, 2.21% Scientific Research Publishing 17 цитирований, 2.21%
Frontiers Media S.A.	Frontiers Media S.A., 16, 2.08% Frontiers Media S.A. 16 цитирований, 2.08%
American Chemical Society (ACS)	American Chemical Society (ACS), 12, 1.56% American Chemical Society (ACS) 12 цитирований, 1.56%
IOP Publishing	IOP Publishing, 8, 1.04% IOP Publishing 8 цитирований, 1.04%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 7, 0.91% Bentham Science Publishers Ltd. 7 цитирований, 0.91%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 7, 0.91% Royal Society of Chemistry (RSC) 7 цитирований, 0.91%
Pleiades Publishing	Pleiades Publishing, 6, 0.78% Pleiades Publishing 6 цитирований, 0.78%
IntechOpen	IntechOpen, 6, 0.78% IntechOpen 6 цитирований, 0.78%
Oxford University Press	Oxford University Press, 5, 0.65% Oxford University Press 5 цитирований, 0.65%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 5, 0.65% Public Library of Science (PLoS) 5 цитирований, 0.65%
Hindawi Limited	Hindawi Limited, 5, 0.65% Hindawi Limited 5 цитирований, 0.65%
SciELO	SciELO, 5, 0.65% SciELO 5 цитирований, 0.65%
openRxiv	openRxiv, 5, 0.65% openRxiv 5 цитирований, 0.65%
SAGE	SAGE, 4, 0.52% SAGE 4 цитирования, 0.52%
American Society for Microbiology	American Society for Microbiology, 4, 0.52% American Society for Microbiology 4 цитирования, 0.52%
AIP Publishing	AIP Publishing, 4, 0.52% AIP Publishing 4 цитирования, 0.52%
PeerJ	PeerJ, 4, 0.52% PeerJ 4 цитирования, 0.52%
Institute of Molecular Biology and Genetics (NAS Ukraine)	Institute of Molecular Biology and Genetics (NAS Ukraine), 4, 0.52% Institute of Molecular Biology and Genetics (NAS Ukraine) 4 цитирования, 0.52%
Academic Journals	Academic Journals, 4, 0.52% Academic Journals 4 цитирования, 0.52%
Academia Brasileira de Ciencias	Academia Brasileira de Ciencias, 3, 0.39% Academia Brasileira de Ciencias 3 цитирования, 0.39%
Cambridge University Press	Cambridge University Press, 2, 0.26% Cambridge University Press 2 цитирования, 0.26%
De Gruyter Brill	De Gruyter Brill, 2, 0.26% De Gruyter Brill 2 цитирования, 0.26%
World Scientific	World Scientific, 2, 0.26% World Scientific 2 цитирования, 0.26%
EDP Sciences	EDP Sciences, 2, 0.26% EDP Sciences 2 цитирования, 0.26%
Pharmaceutical Society of Japan	Pharmaceutical Society of Japan, 2, 0.26% Pharmaceutical Society of Japan 2 цитирования, 0.26%
King Saud University	King Saud University, 2, 0.26% King Saud University 2 цитирования, 0.26%
Brazilian Society of Chemical Engineering	Brazilian Society of Chemical Engineering, 2, 0.26% Brazilian Society of Chemical Engineering 2 цитирования, 0.26%
Journal of Pure and Applied Microbiology	Journal of Pure and Applied Microbiology, 2, 0.26% Journal of Pure and Applied Microbiology 2 цитирования, 0.26%
Southwestern Entomological Society	Southwestern Entomological Society, 2, 0.26% Southwestern Entomological Society 2 цитирования, 0.26%
Instituto de Tecnologia do Parana	Instituto de Tecnologia do Parana, 2, 0.26% Instituto de Tecnologia do Parana 2 цитирования, 0.26%
Rockefeller University Press	Rockefeller University Press, 1, 0.13% Rockefeller University Press 1 цитирование, 0.13%
Trans Tech Publications	Trans Tech Publications, 1, 0.13% Trans Tech Publications 1 цитирование, 0.13%
American Institute of Mathematical Sciences (AIMS)	American Institute of Mathematical Sciences (AIMS), 1, 0.13% American Institute of Mathematical Sciences (AIMS) 1 цитирование, 0.13%
Taras Shevchenko National University of Kyiv	Taras Shevchenko National University of Kyiv, 1, 0.13% Taras Shevchenko National University of Kyiv 1 цитирование, 0.13%
State Research Institute for Genetics and Selection of Industrial Microorganisms	State Research Institute for Genetics and Selection of Industrial Microorganisms, 1, 0.13% State Research Institute for Genetics and Selection of Industrial Microorganisms 1 цитирование, 0.13%
National Institute of Genetic Engineering and Biotechnology	National Institute of Genetic Engineering and Biotechnology, 1, 0.13% National Institute of Genetic Engineering and Biotechnology 1 цитирование, 0.13%
Pensoft Publishers	Pensoft Publishers, 1, 0.13% Pensoft Publishers 1 цитирование, 0.13%
Faculty of Agriculture, Ain-Shams University	Faculty of Agriculture, Ain-Shams University, 1, 0.13% Faculty of Agriculture, Ain-Shams University 1 цитирование, 0.13%
Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society	Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society, 1, 0.13% Hrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society 1 цитирование, 0.13%
Korean Society for Microbiolog and Biotechnology	Korean Society for Microbiolog and Biotechnology, 1, 0.13% Korean Society for Microbiolog and Biotechnology 1 цитирование, 0.13%
Korean Society for Biotechnology and Bioengineering	Korean Society for Biotechnology and Bioengineering, 1, 0.13% Korean Society for Biotechnology and Bioengineering 1 цитирование, 0.13%
Hanguk Misaengmul Hakhoe	Hanguk Misaengmul Hakhoe, 1, 0.13% Hanguk Misaengmul Hakhoe 1 цитирование, 0.13%
Kemerovo State University	Kemerovo State University, 1, 0.13% Kemerovo State University 1 цитирование, 0.13%
Science in China Press	Science in China Press, 1, 0.13% Science in China Press 1 цитирование, 0.13%
Korean Society for Clinical Pharmacology and Therapeutics	Korean Society for Clinical Pharmacology and Therapeutics, 1, 0.13% Korean Society for Clinical Pharmacology and Therapeutics 1 цитирование, 0.13%
eLife Sciences Publications	eLife Sciences Publications, 1, 0.13% eLife Sciences Publications 1 цитирование, 0.13%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 0.13% Cold Spring Harbor Laboratory 1 цитирование, 0.13%
Institute of Electrical and Electronics Engineers (IEEE)	Institute of Electrical and Electronics Engineers (IEEE), 1, 0.13% Institute of Electrical and Electronics Engineers (IEEE) 1 цитирование, 0.13%
Science Alert	Science Alert, 1, 0.13% Science Alert 1 цитирование, 0.13%
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)	National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications), 1, 0.13% National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications) 1 цитирование, 0.13%
Social Science Electronic Publishing	Social Science Electronic Publishing, 1, 0.13% Social Science Electronic Publishing 1 цитирование, 0.13%
CMV Verlag	CMV Verlag, 1, 0.13% CMV Verlag 1 цитирование, 0.13%
OAE Publishing Inc.	OAE Publishing Inc., 1, 0.13% OAE Publishing Inc. 1 цитирование, 0.13%
A and V Publications	A and V Publications, 1, 0.13% A and V Publications 1 цитирование, 0.13%
Irkutsk National Research Technical University	Irkutsk National Research Technical University, 1, 0.13% Irkutsk National Research Technical University 1 цитирование, 0.13%
Japan Oil Chemists' Society	Japan Oil Chemists' Society, 1, 0.13% Japan Oil Chemists' Society 1 цитирование, 0.13%
IGI Global	IGI Global, 1, 0.13% IGI Global 1 цитирование, 0.13%
FSBSI FRC N.I. Vavilov All-Russian Institute of Plant Genetic Resources	FSBSI FRC N.I. Vavilov All-Russian Institute of Plant Genetic Resources, 1, 0.13% FSBSI FRC N.I. Vavilov All-Russian Institute of Plant Genetic Resources 1 цитирование, 0.13%
Maximum Academic Press	Maximum Academic Press, 1, 0.13% Maximum Academic Press 1 цитирование, 0.13%
SFSCA RAS	SFSCA RAS, 1, 0.13% SFSCA RAS 1 цитирование, 0.13%
Institutul de Chimie Macromoleculara Petru Poni	Institutul de Chimie Macromoleculara Petru Poni, 1, 0.13% Institutul de Chimie Macromoleculara Petru Poni 1 цитирование, 0.13%
Korean Society for Microbiology and Biotechnology	Korean Society for Microbiology and Biotechnology, 1, 0.13% Korean Society for Microbiology and Biotechnology 1 цитирование, 0.13%

	50 100 150 200 250