Phytotherapy Research, volume 21, issue 8, pages 731-734
Anticancer activity of limonoid from Khaya senegalensis
Huaping Zhang
1
,
Xi Wang
1
,
F.C. Chen
1
,
X. Michelle Androulakis
2
,
Michael J. Wargovich
2
Publication type: Journal Article
Publication date: 2007-04-20
Journal:
Phytotherapy Research
scimago Q1
SJR: 1.277
CiteScore: 12.8
Impact factor: 6.1
ISSN: 0951418X, 10991573
DOI:
10.1002/ptr.2148
PubMed ID:
17450502
Pharmacology
Abstract
Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3alpha,7alpha-dideacetylkhivorin (1) and 1-O-acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of (1)H and (13)C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, (1)H-(1)H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF-7, SiHa and Caco-2 cells with IC(50) values in the range of 0.07-0.14 microm (35-69 ppm) while compound 2 did not.
Found
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