Angewandte Chemie - International Edition, том 60, издание 34, номера страниц: 18694-18703

Gausemycins A,B: Cyclic Lipoglycopeptides from Streptomyces sp.**

Alferova Vera A. 1, 2
Baranova Anna A. 1, 2
Ivanov Igor A. 2
Kravchenko Tatyana V. 1, 2
Isakova Elena B. 1
Mirchink Elena P. 1
Gladkikh Elena G. 1
Kulyaeva Valeriya V. 1
Shashkov Alexander S. 8
Tsvetkov Dmitry E. 8
Katrukha Genrikh S. 1
Lapchinskaya Olda A. 1
Dontsova Olga A. 2, 3, 4
Osterman Ilya A. 3, 4
Тип документаJournal Article
Дата публикации2021-06-22
ИздательWiley
Название журналаAngewandte Chemie - International Edition
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 202116.82
ISSN14337851, 15213773
General Chemistry
Catalysis
Краткое описание
We report a novel family of natural lipoglycopeptides produced by Streptomyces sp. INA-Ac-5812. Two major components of the mixture, named gausemycins A and B, were isolated, and their structures were elucidated. The compounds are cyclic peptides with a unique peptide core and several remarkable structural features, including unusual positions of D-amino acids, lack of the Ca 2+ -binding Asp-X-Asp-Gly (DXDG) motif, tyrosine glycosylation with arabinose, presence of 2-amino-4-hydroxy-4-phenylbutyric acid (Ahpb) and chlorinated kynurenine (ClKyn), N -acylation of the ornithine side chain. Gausemycins have pronounced activity against Gram-positive bacteria. Mechanistic studies highlight significant differences compared to known glyco- and lipopeptides. Gausemycins exhibit only slight Ca 2+ -dependence of activity and induce no pore formation at low concentrations. Moreover, there is no detectable accumulation of cell wall biosynthesis precursors under treatment with gausemycins.
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1. Tyurin A.P. и др. Gausemycins A,B: Cyclic Lipoglycopeptides from Streptomyces sp.** // Angewandte Chemie International Edition. 2021. Т. 60. № 34. С. 18694–18703.
RIS |
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TY - JOUR

DO - 10.1002/anie.202104528

UR - http://dx.doi.org/10.1002/anie.202104528

TI - Gausemycins A,B: Cyclic Lipoglycopeptides from

Streptomyces

sp.**

T2 - Angewandte Chemie International Edition

AU - Tyurin, Anton P.

AU - Alferova, Vera A.

AU - Paramonov, Alexander S.

AU - Shuvalov, Maxim V.

AU - Kudryakova, Gulnara K.

AU - Rogozhin, Eugene A.

AU - Zherebker, Alexander Y.

AU - Brylev, Vladimir A.

AU - Chistov, Alexey A.

AU - Baranova, Anna A.

AU - Biryukov, Mikhail V.

AU - Ivanov, Igor A.

AU - Prokhorenko, Igor A.

AU - Grammatikova, Natalia E.

AU - Kravchenko, Tatyana V.

AU - Isakova, Elena B.

AU - Mirchink, Elena P.

AU - Gladkikh, Elena G.

AU - Svirshchevskaya, Elena V.

AU - Mardanov, Andrey V.

AU - Beletsky, Aleksey V.

AU - Kocharovskaya, Milita V.

AU - Kulyaeva, Valeriya V.

AU - Shashkov, Alexander S.

AU - Tsvetkov, Dmitry E.

AU - Nifantiev, Nikolay E.

AU - Apt, Alexander S.

AU - Majorov, Konstantin B.

AU - Efimova, Svetlana S.

AU - Ravin, Nikolai V.

AU - Nikolaev, Evgeny N.

AU - Ostroumova, Olga S.

AU - Katrukha, Genrikh S.

AU - Lapchinskaya, Olda A.

AU - Dontsova, Olga A.

AU - Terekhov, Stanislav S.

AU - Osterman, Ilya A.

AU - Shenkarev, Zakhar O.

AU - Korshun, Vladimir A.

PY - 2021

DA - 2021/06/22

PB - Wiley

SP - 18694-18703

IS - 34

VL - 60

SN - 1433-7851

SN - 1521-3773

ER -

BibTex |
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@article{2021,

doi = {10.1002/anie.202104528},

url = {https://doi.org/10.1002%2Fanie.202104528},

year = 2021,

month = {jun},

publisher = {Wiley},

volume = {60},

number = {34},

pages = {18694--18703},

author = {Anton P. Tyurin and Vera A. Alferova and Alexander S. Paramonov and Maxim V. Shuvalov and Gulnara K. Kudryakova and Eugene A. Rogozhin and Alexander Y. Zherebker and Vladimir A. Brylev and Alexey A. Chistov and Anna A. Baranova and Mikhail V. Biryukov and Igor A. Ivanov and Igor A. Prokhorenko and Natalia E. Grammatikova and Tatyana V. Kravchenko and Elena B. Isakova and Elena P. Mirchink and Elena G. Gladkikh and Elena V. Svirshchevskaya and Andrey V. Mardanov and Aleksey V. Beletsky and Milita V. Kocharovskaya and Valeriya V. Kulyaeva and Alexander S. Shashkov and Dmitry E. Tsvetkov and Nikolay E. Nifantiev and Alexander S. Apt and Konstantin B. Majorov and Svetlana S. Efimova and Nikolai V. Ravin and Evgeny N. Nikolaev and Olga S. Ostroumova and Genrikh S. Katrukha and Olda A. Lapchinskaya and Olga A. Dontsova and Stanislav S. Terekhov and Ilya A. Osterman and Zakhar O. Shenkarev and Vladimir A. Korshun},

title = {Gausemycins{\hspace{0.25em}}A,B: Cyclic Lipoglycopeptides from

Streptomyces

sp.{\ast}{\ast}}

}

MLA
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Tyurin, Anton P. et al. “Gausemycins A,B: Cyclic Lipoglycopeptides from Streptomyces Sp.**.” Angewandte Chemie International Edition 60.34 (2021): 18694–18703. Crossref. Web.