Open Access
Current advances on the therapeutic potential of pinocembrin: An updated review
2
Agrobiosciences, Mohamed IV Polytechnic University, Lot 660, Hay Moulay Rachid, Ben-Guerir 43150, Morocco
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Publication type: Journal Article
Publication date: 2023-01-01
scimago Q1
wos Q1
SJR: 1.775
CiteScore: 12.8
Impact factor: 7.5
ISSN: 07533322, 19506007
PubMed ID:
36481404
General Medicine
Pharmacology
Abstract
Pinocembrin (5,7-dihydroxyflavone) is a major flavonoid found in many plants, fungi and hive products, mainly honey and propolis. Several in vitro and preclinical studies revealed numerous pharmacological activities of pinocembrin including antioxidant, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective and anticancer activities. Here, we comprehensively review and critically analyze the studies carried out on pinocembrin. We also discuss its potential mechanisms of action, bioavailability, toxicity, and clinical investigations. The wide therapeutic window of pinocembrin makes it a promising drug candidate for many clinical applications. We recommend some future perspectives to improve its pharmacokinetic and pharmacodynamic properties for better delivery that may also lead to new therapeutic advances.
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82
Total citations:
82
Citations from 2024:
73
(91.25%)
Cite this
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RIS |
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GOST
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Elbatreek M. H. et al. Current advances on the therapeutic potential of pinocembrin: An updated review // Biomedicine and Pharmacotherapy. 2023. Vol. 157. p. 114032.
GOST all authors (up to 50)
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Elbatreek M. H., Mahdi I., Ouchari W., Mahmoud M. F., Sobeh M. Current advances on the therapeutic potential of pinocembrin: An updated review // Biomedicine and Pharmacotherapy. 2023. Vol. 157. p. 114032.
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RIS
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TY - JOUR
DO - 10.1016/j.biopha.2022.114032
UR - https://doi.org/10.1016/j.biopha.2022.114032
TI - Current advances on the therapeutic potential of pinocembrin: An updated review
T2 - Biomedicine and Pharmacotherapy
AU - Elbatreek, Mahmoud H.
AU - Mahdi, Ismail
AU - Ouchari, Wafae
AU - Mahmoud, Mona F.
AU - Sobeh, Mansour
PY - 2023
DA - 2023/01/01
PB - Elsevier
SP - 114032
VL - 157
PMID - 36481404
SN - 0753-3322
SN - 1950-6007
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Elbatreek,
author = {Mahmoud H. Elbatreek and Ismail Mahdi and Wafae Ouchari and Mona F. Mahmoud and Mansour Sobeh},
title = {Current advances on the therapeutic potential of pinocembrin: An updated review},
journal = {Biomedicine and Pharmacotherapy},
year = {2023},
volume = {157},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.biopha.2022.114032},
pages = {114032},
doi = {10.1016/j.biopha.2022.114032}
}