Fabrication of phenylalanine amidated pectin using ultra-low temperature enzymatic method and its hydrogel properties in drug sustained release application
Publication type: Journal Article
Publication date: 2022-09-01
scimago Q1
wos Q1
SJR: 1.285
CiteScore: 10.3
Impact factor: 8.5
ISSN: 01418130, 18790003
PubMed ID:
35788006
Biochemistry
Molecular Biology
General Medicine
Structural Biology
Abstract
In this study, pectin was modified with phenylalanine by ultra-low temperature enzymatic method to improve its gel properties. The grafting ratio of phenylalanine amidated pectin was studied under different reaction conditions. The highest value (29.21 %) was reached a reaction temperature of -5 °C and time of 12 h. Further analysis indicated that phenylalanine and high methoxyl pectin combined at the solid-liquid two phase interface under the catalysis of papain to form phenylalanine amidated pectin. Moreover, the physicochemical properties of pectin hydrogel and its feasibility as a sustained-release drug carrier were discussed. The results showed that phenylalanine amidated pectin can form hydrogel with a certain strength under acidic conditions, and there is no need to add a lot of soluble solids and divalent cations. Besides, the phenylalanine amidated pectin hydrogel as a sustained release carrier of drugs showed more sustained and complete drug release.
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19
Total citations:
19
Citations from 2025:
7
(36.84%)
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GOST
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Zheng C. et al. Fabrication of phenylalanine amidated pectin using ultra-low temperature enzymatic method and its hydrogel properties in drug sustained release application // International Journal of Biological Macromolecules. 2022. Vol. 216. pp. 263-271.
GOST all authors (up to 50)
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Zheng C., Huang W., Zou Y., HUANG W., Peng F., Zhang G. Fabrication of phenylalanine amidated pectin using ultra-low temperature enzymatic method and its hydrogel properties in drug sustained release application // International Journal of Biological Macromolecules. 2022. Vol. 216. pp. 263-271.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.ijbiomac.2022.06.174
UR - https://doi.org/10.1016/j.ijbiomac.2022.06.174
TI - Fabrication of phenylalanine amidated pectin using ultra-low temperature enzymatic method and its hydrogel properties in drug sustained release application
T2 - International Journal of Biological Macromolecules
AU - Zheng, Chenmin
AU - Huang, Wanping
AU - Zou, Yuping
AU - HUANG, WENSI
AU - Peng, Fei
AU - Zhang, Guoguang
PY - 2022
DA - 2022/09/01
PB - Elsevier
SP - 263-271
VL - 216
PMID - 35788006
SN - 0141-8130
SN - 1879-0003
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Zheng,
author = {Chenmin Zheng and Wanping Huang and Yuping Zou and WENSI HUANG and Fei Peng and Guoguang Zhang},
title = {Fabrication of phenylalanine amidated pectin using ultra-low temperature enzymatic method and its hydrogel properties in drug sustained release application},
journal = {International Journal of Biological Macromolecules},
year = {2022},
volume = {216},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.ijbiomac.2022.06.174},
pages = {263--271},
doi = {10.1016/j.ijbiomac.2022.06.174}
}