Reductive Amination in the Synthesis of Pharmaceuticals.
Publication type: Journal Article
Publication date: 2019-10-21
scimago Q1
wos Q1
SJR: 16.455
CiteScore: 100.5
Impact factor: 55.8
ISSN: 00092665, 15206890
PubMed ID:
31633341
General Chemistry
Abstract
Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous presence of amines among biologically active compounds. It is one of the key approaches to C-N bond construction due to its operational easiness and a wide toolbox of protocols. Recent studies show that at least a quarter of C-N bond-forming reactions in the pharmaceutical industry are performed via reductive amination. This Review concisely compiles information on 71 medical substances that are synthesized by reductive amination. Compounds are grouped according to the principle of action, which includes drugs affecting the central nervous system, drugs affecting the cardiovascular system, anticancer drugs, antibiotics, antiviral and antifungal medicines, drugs affecting the urinary system, drugs affecting the respiratory system, antidiabetic medications, drugs affecting the gastrointestinal tract, and drugs regulating metabolic processes. A general synthetic scheme is provided for each compound, and the description is focused on reductive amination steps. The green chemistry metric of reaction mass efficiency was calculated for all reactions.
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Metrics
666
Total citations:
666
Citations from 2024:
296
(44.52%)
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GOST
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Afanasyev O. I. et al. Reductive Amination in the Synthesis of Pharmaceuticals. // Chemical Reviews. 2019. Vol. 119. No. 23. pp. 11857-11911.
GOST all authors (up to 50)
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Afanasyev O. I., Kuchuk E., Usanov D. A., Chusov D. Reductive Amination in the Synthesis of Pharmaceuticals. // Chemical Reviews. 2019. Vol. 119. No. 23. pp. 11857-11911.
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RIS
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TY - JOUR
DO - 10.1021/acs.chemrev.9b00383
UR - https://doi.org/10.1021/acs.chemrev.9b00383
TI - Reductive Amination in the Synthesis of Pharmaceuticals.
T2 - Chemical Reviews
AU - Afanasyev, Oleg I
AU - Kuchuk, Ekaterina
AU - Usanov, Dmitry A.
AU - Chusov, Denis
PY - 2019
DA - 2019/10/21
PB - American Chemical Society (ACS)
SP - 11857-11911
IS - 23
VL - 119
PMID - 31633341
SN - 0009-2665
SN - 1520-6890
ER -
Cite this
BibTex (up to 50 authors)
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@article{2019_Afanasyev,
author = {Oleg I Afanasyev and Ekaterina Kuchuk and Dmitry A. Usanov and Denis Chusov},
title = {Reductive Amination in the Synthesis of Pharmaceuticals.},
journal = {Chemical Reviews},
year = {2019},
volume = {119},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acs.chemrev.9b00383},
number = {23},
pages = {11857--11911},
doi = {10.1021/acs.chemrev.9b00383}
}
Cite this
MLA
Copy
Afanasyev, Oleg I., et al. “Reductive Amination in the Synthesis of Pharmaceuticals..” Chemical Reviews, vol. 119, no. 23, Oct. 2019, pp. 11857-11911. https://doi.org/10.1021/acs.chemrev.9b00383.
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