Hitchhiker’s Guide to Reductive Amination
Publication type: Journal Article
Publication date: 2019-04-17
scimago Q2
wos Q2
SJR: 0.559
CiteScore: 4.6
Impact factor: 2.3
ISSN: 00397881, 1437210X
Catalysis
Organic Chemistry
Abstract
A comparative study of various widely used methods of reductive amination is reported. Specifically, such reducing agents as H2, Pd/C, hydride reagents [NaBH4, NaBH3CN, NaBH(OAc)3], and CO/Rh2(OAc)4 system were considered. For understanding the selectivity and activity of the reducing agents reviewed herein, different classes of starting materials were tested, including aliphatic and aromatic amines, as well as aliphatic and aromatic aldehydes and ketones. Most important advantages and drawbacks of the methods, such as selectivity of the target amine formation and toxicity of the reducing agents were compared. Methods were also considered from the viewpoint of green chemistry.
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Metrics
83
Total citations:
83
Citations from 2025:
13
(15.66%)
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GOST
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Podyacheva E. et al. Hitchhiker’s Guide to Reductive Amination // Synthesis. 2019. Vol. 51. No. 13. pp. 2667-2677.
GOST all authors (up to 50)
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Podyacheva E., Afanasyev O. I., Tsygankov A. A., Makarova M., Chusov D. Hitchhiker’s Guide to Reductive Amination // Synthesis. 2019. Vol. 51. No. 13. pp. 2667-2677.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1055/s-0037-1611788
UR - https://doi.org/10.1055/s-0037-1611788
TI - Hitchhiker’s Guide to Reductive Amination
T2 - Synthesis
AU - Podyacheva, Evgeniya
AU - Afanasyev, Oleg I
AU - Tsygankov, Alexey A.
AU - Makarova, Maria
AU - Chusov, Denis
PY - 2019
DA - 2019/04/17
PB - Georg Thieme Verlag KG
SP - 2667-2677
IS - 13
VL - 51
SN - 0039-7881
SN - 1437-210X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Podyacheva,
author = {Evgeniya Podyacheva and Oleg I Afanasyev and Alexey A. Tsygankov and Maria Makarova and Denis Chusov},
title = {Hitchhiker’s Guide to Reductive Amination},
journal = {Synthesis},
year = {2019},
volume = {51},
publisher = {Georg Thieme Verlag KG},
month = {apr},
url = {https://doi.org/10.1055/s-0037-1611788},
number = {13},
pages = {2667--2677},
doi = {10.1055/s-0037-1611788}
}
Cite this
MLA
Copy
Podyacheva, Evgeniya, et al. “Hitchhiker’s Guide to Reductive Amination.” Synthesis, vol. 51, no. 13, Apr. 2019, pp. 2667-2677. https://doi.org/10.1055/s-0037-1611788.