Open Access

Biomolecules

, volume 12 , issue 3 , pages 472

Glucose Oxidase, an Enzyme “Ferrari”: Its Structure, Function, Production and Properties in the Light of Various Industrial and Biotechnological Applications

JACOB H. BAUER ¹

Monika Zámocká ¹

Juraj Majtan ^{1, 2}

Vladena Bauerova-Hlinkova ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Institute of Molecular Biology, Slovak Academy of Sciences, 845 51 Bratislava, Slovakia |

Department of Microbiology, Faculty of Medicine, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia |

Publication type: Journal Article

Publication date: 2022-03-19

MDPI

Biomolecules

scimago Q1

wos Q1

SJR: 1.333

CiteScore: 9.2

Impact factor: 4.8

ISSN: 2218273X

DOI: 10.3390/biom12030472

Copy DOI

PubMed ID: 35327664

Biochemistry

Molecular Biology

Abstract

Glucose oxidase (GOx) is an important oxidoreductase enzyme with many important roles in biological processes. It is considered an “ideal enzyme” and is often called an oxidase “Ferrari” because of its fast mechanism of action, high stability and specificity. Glucose oxidase catalyzes the oxidation of β-d-glucose to d-glucono-δ-lactone and hydrogen peroxide in the presence of molecular oxygen. d-glucono-δ-lactone is sequentially hydrolyzed by lactonase to d-gluconic acid, and the resulting hydrogen peroxide is hydrolyzed by catalase to oxygen and water. GOx is presently known to be produced only by fungi and insects. The current main industrial producers of glucose oxidase are Aspergillus and Penicillium. An important property of GOx is its antimicrobial effect against various pathogens and its use in many industrial and medical areas. The aim of this review is to summarize the structure, function, production strains and biophysical and biochemical properties of GOx in light of its various industrial, biotechnological and medical applications.

Found

1 citation

Kuznetsova Iren

DSc in Physics and Mathematics, associate professor

258 publications, 2 543 citations, 63 reviews

h-index: 25

Kotelnikov Institute of Radioengineering and Electronics of the Russian Academy of Sciences

1 citation

Gaynanova Gulnara

PhD in Chemistry

74 publications, 1 073 citations, 1 review

h-index: 18

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Colloidal chemistry

Drug delivery systems

Physical Chemistry

Supramolecular chemistry

Surfactants

1 citation

Vasilyeva Leysan

PhD in Chemistry

29 publications, 492 citations

h-index: 14

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Colloidal chemistry

Drug delivery systems

Physical Chemistry

Surfactants

1 citation

Zakharova Lucia

DSc in Chemistry, professor

394 publications, 6 176 citations

h-index: 36

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

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BAUER J. H. et al. Glucose Oxidase, an Enzyme “Ferrari”: Its Structure, Function, Production and Properties in the Light of Various Industrial and Biotechnological Applications // Biomolecules. 2022. Vol. 12. No. 3. p. 472.

GOST all authors (up to 50) Copy

BAUER J. H., Zámocká M., Majtan J., Bauerova-Hlinkova V. Glucose Oxidase, an Enzyme “Ferrari”: Its Structure, Function, Production and Properties in the Light of Various Industrial and Biotechnological Applications // Biomolecules. 2022. Vol. 12. No. 3. p. 472.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/biom12030472

UR - https://doi.org/10.3390/biom12030472

TI - Glucose Oxidase, an Enzyme “Ferrari”: Its Structure, Function, Production and Properties in the Light of Various Industrial and Biotechnological Applications

T2 - Biomolecules

AU - BAUER, JACOB H.

AU - Zámocká, Monika

AU - Majtan, Juraj

AU - Bauerova-Hlinkova, Vladena

PY - 2022

DA - 2022/03/19

PB - MDPI

SP - 472

IS - 3

VL - 12

PMID - 35327664

SN - 2218-273X

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2022_BAUER,

author = {JACOB H. BAUER and Monika Zámocká and Juraj Majtan and Vladena Bauerova-Hlinkova},

title = {Glucose Oxidase, an Enzyme “Ferrari”: Its Structure, Function, Production and Properties in the Light of Various Industrial and Biotechnological Applications},

journal = {Biomolecules},

year = {2022},

volume = {12},

publisher = {MDPI},

month = {mar},

url = {https://doi.org/10.3390/biom12030472},

number = {3},

pages = {472},

doi = {10.3390/biom12030472}

}

MLA

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MLA Copy

BAUER, JACOB H., et al. “Glucose Oxidase, an Enzyme “Ferrari”: Its Structure, Function, Production and Properties in the Light of Various Industrial and Biotechnological Applications.” Biomolecules, vol. 12, no. 3, Mar. 2022, p. 472. https://doi.org/10.3390/biom12030472.

Publisher

MDPI

Journal

Biomolecules

scimago Q1

wos Q1

SJR

1.333

CiteScore

9.2

Impact factor

4.8

ISSN

2218273X (Electronic)