Central Research Laboratory of the Federal State Budgetary Educational Institution of Higher Medical Education of the Ministry of Health of the Russian Federation

1. Major obstetric syndromes: prognosis, prevention. 2. The influence of endocrine factors on the development and structural and functional state of life support systems. 3. Study of the properties of pathogens, pathogenesis, improvement of diagnostic and treatment methods in infectious diseases. 4. Study of somatic manifestations of anxiety– depressive disorders and psycho–emotional stress in practically healthy individuals and in some chronic non-communicable diseases. 5. Innovative therapeutic, diagnostic and preventive approaches for endocrine pathology of the reproductive system in different periods of a woman's life. 6. Clinical, diagnostic and preventive aspects of combined diseases of internal organs in the population of the Southern Urals. 7. Clinical, diagnostic, therapeutic, preventive and rehabilitative aspects of diseases of the nervous system. 8. Clinical and laboratory aspects of the diagnosis and treatment of surgical infections. 9. Clinical, pathogenetic and therapeutic aspects of critical and terminal conditions in intensive care patients, the role of anesthetic aids in the formation of critical conditions. 10. Minimally invasive and innovative treatment technologies in traumatology and orthopedics. 11. Medical and social problems of assessment and formation of dental health, improvement of clinical, diagnostic and preventive measures in the provision of dental care, improvement of the management system and quality control of dental care to the population. 12. Pathogenetic justification of the use of melatonin in the current non-infectious pathology. 13. Pathomorphological characteristics, morphogenesis, pathomorphosis of infectious and non-communicable human diseases and aspects of polymorbidity in the population of the Southern Urals. 14. Pathomorphological, immunological aspects of pathogenesis and therapy in dermatovenerology and cosmetology. 15. Prediction and prevention of cardiovascular risk in young people. 16. Forecasting the course and complications of diseases of the nervous system. 17. Development and substantiation of medical rehabilitation technologies for acute and chronic non-communicable diseases. 18. Development of new high-tech technological approaches in high-tech dental rehabilitation of patients. 19. Early diagnosis of cardiovascular complications of obesity in children: a personalized approach. 20. Redox regulation of protein and amino acid metabolism under conditions of oxidative stress and its role in the development and outcomes of pathological processes. 21. The role of innate immunity in the pathogenesis of diseases of the digestive system. 22. The role of innate immunity in the pathogenesis of digestive diseases. 23. The role of genetic polymorphisms in the etiology and pathogenesis of multifactorial human diseases. 24. The role of changes in immune status and hemostasis in the pathogenesis and prognosis of abdominal sepsis. 25. The role of changes in immune status and hemostasis in the pathogenesis and prognosis of abdominal sepsis. 26. Improvement of diagnostic and therapeutic approaches in dental practice through the use of innovative therapeutic and diagnostic technologies. 27. Improving the diagnosis, treatment, and prevention of combined pathology in cardiovascular patients. 28. Improvement of diagnostic methods and pathogenetically oriented treatment of inflammatory, vascular, dystrophic, tumor diseases and damage to the organ of vision. 29. Improvement of methods of diagnosis and prevention of atherosclerosis complications in patients with inflammatory bowel diseases (state task). 30. Improving the understanding of microbial ecology and human anti-infective protection factors in normal and pathological conditions to develop new approaches to microbiome management. 31. Pharmacology of domestic derivatives of 3-hydroxypyridine and succinic acid and their use in the treatment of human diseases.