Rajiv Gandhi Proudyogiki Vishwavidyalaya

Pathak Y., Shukla P.K., Tiwari A., Stalin S., Singh S., Shukla P.K.

The COVID-19 infection is increasing at a rapid rate, with the availability of limited number of testing kits. Therefore, the development of COVID-19 testing kits is still an open area of research. Recently, many studies have shown that chest Computed Tomography (CT) images can be used for COVID-19 testing, as chest CT images show a bilateral change in COVID-19 infected patients. However, the classification of COVID-19 patients from chest CT images is not an easy task as predicting the bilateral change is defined as an ill-posed problem. Therefore, in this paper, a deep transfer learning technique is used to classify COVID-19 infected patients. Additionally, a top-2 smooth loss function with cost-sensitive attributes is also utilized to handle noisy and imbalanced COVID-19 dataset kind of problems. Experimental results reveal that the proposed deep transfer learning-based COVID-19 classification model provides efficient results as compared to the other supervised learning models.

Stalin S., Roy V., Shukla P.K., Zaguia A., Khan M.M., Shukla P.K., Jain A.

The electroencephalogram (EEG) signals are a big data which are frequently corrupted by motion artifacts. As human neural diseases, diagnosis and analysis need a robust neurological signal. Consequently, the EEG artifacts’ eradication is a vital step. In this research paper, the primary motion artifact is detected from a single-channel EEG signal using support vector machine (SVM) and preceded with further artifacts’ suppression. The signal features’ abstraction and further detection are done through ensemble empirical mode decomposition (EEMD) algorithm. Moreover, canonical correlation analysis (CCA) filtering approach is applied for motion artifact removal. Finally, leftover motion artifacts’ unpredictability is removed by applying wavelet transform (WT) algorithm. Finally, results are optimized by using Harris hawks optimization (HHO) algorithm. The results of the assessment confirm that the algorithm recommended is superior to the algorithms currently in use.

Sundararaj V., Anoop V., Dixit P., Arjaria A., Chourasia U., Bhambri P., M R R., Sundararaj R.

Shukla P.K., Sandhu J.K., Ahirwar A., Ghai D., Maheshwary P., Shukla P.K.

COVID-19 is a new disease, caused by the novel coronavirus SARS-CoV-2, that was firstly delineated in humans in 2019. Coronaviruses cause a range of illness in patients varying from common cold to advanced respiratory syndromes such as Severe Acute Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV). The SARS-CoV-2 outbreak has resulted in a global pandemic, and its transmission is increasing at a rapid rate. Diagnostic testing and approaches provide a valuable tool for doctors and support them with the screening process. Automatic COVID-19 identification in chest X-ray images can be useful to test for COVID-19 infection at a good speed. Therefore, in this paper, a framework is designed by using Convolutional Neural Networks (CNN) to diagnose COVID-19 patients using chest X-ray images. A pretrained GoogLeNet is utilized for implementing the transfer learning (i.e., by replacing some sets of final network CNN layers). 20-fold cross-validation is considered to overcome the overfitting quandary. Finally, the multiobjective genetic algorithm is considered to tune the hyperparameters of the proposed COVID-19 identification in chest X-ray images. Extensive experiments show that the proposed COVID-19 identification model obtains remarkably better results and may be utilized for real-time testing of patients.

Krishnamoorthi R., Joshi S., Almarzouki H.Z., Shukla P.K., Rizwan A., Kalpana C., Tiwari B.

Diabetes is a chronic disease that continues to be a significant and global concern since it affects the entire population’s health. It is a metabolic disorder that leads to high blood sugar levels and many other problems such as stroke, kidney failure, and heart and nerve problems. Several researchers have attempted to construct an accurate diabetes prediction model over the years. However, this subject still faces significant open research issues due to a lack of appropriate data sets and prediction approaches, which pushes researchers to use big data analytics and machine learning (ML)-based methods. Applying four different machine learning methods, the research tries to overcome the problems and investigate healthcare predictive analytics. The study’s primary goal was to see how big data analytics and machine learning-based techniques may be used in diabetes. The examination of the results shows that the suggested ML-based framework may achieve a score of 86. Health experts and other stakeholders are working to develop categorization models that will aid in the prediction of diabetes and the formulation of preventative initiatives. The authors perform a review of the literature on machine models and suggest an intelligent framework for diabetes prediction based on their findings. Machine learning models are critically examined, and an intelligent machine learning-based architecture for diabetes prediction is proposed and evaluated by the authors. In this study, the authors utilize our framework to develop and assess decision tree (DT)-based random forest (RF) and support vector machine (SVM) learning models for diabetes prediction, which are the most widely used techniques in the literature at the time of writing. It is proposed in this study that a unique intelligent diabetes mellitus prediction framework (IDMPF) is developed using machine learning. According to the framework, it was developed after conducting a rigorous review of existing prediction models in the literature and examining their applicability to diabetes. Using the framework, the authors describe the training procedures, model assessment strategies, and issues associated with diabetes prediction, as well as solutions they provide. The findings of this study may be utilized by health professionals, stakeholders, students, and researchers who are involved in diabetes prediction research and development. The proposed work gives 83% accuracy with the minimum error rate.

Dixit P., Silakari S.

Cybersecurity mainly prevents the hardware, software, and data present in the system that has an active internet connection from external attacks. Organizations mainly deploy cybersecurity for their databases and systems to prevent it from unauthorized access. Different forms of attacks like phishing, spear-phishing, a drive-by attack, a password attack, denial of service, etc. are responsible for these security problems In this survey, we analyzed and reviewed the usage of deep learning algorithms for Cybersecurity applications. Deep learning which is also known as Deep Neural Networks includes machine learning techniques that enable the network to learn from unsupervised data and solve complex problems. Here, 80 papers from 2014 to 2019 have been used and successfully analyzed. Deep learning approaches such as Convolutional Neural Network (CNN), Auto Encoder (AE), Deep Belief Network (DBN), Recurrent Neural Network (RNN), Generative Adversal Network (GAN) and Deep Reinforcement Learning (DIL) are used to categorize the papers referred. Each specific technique is effectively discussed with its algorithms, platforms, dataset, and potential benefits. The paper related to deep learning with cybersecurity is mainly published in the year 2018 in a large number and 18% of published articles originate from the UK. In addition, the papers are selected from a variety of journals, and 30% of papers used are from the Elsevier journal. From the experimental analysis, it is clear that the deep learning model improved the accuracy, scalability, reliability, and performance of the cybersecurity applications when applied in realtime.

Shukla P.K., Roy V., Shukla P.K., Chaturvedi A.K., Saxena A.K., Maheshwari M., Pal P.R.

Abstract The electroencephalography (EEG) signal is corrupted with some non-cerebral activities due to patient movement during signal measurement. These non-cerebral activities are termed as artifacts, which may diminish the superiority of acquired EEG signal statistics. The state of the art artifact elimination approaches applied canonical correlation analysis (CCA) for confiscating EEG motion artifacts accompanied by ensemble empirical mode decomposition (EEMD). An improved cascaded approach based on Gaussian elimination CCA (GECCA) and EEMD is applied to suppress EEG artifacts effectively. However, in a highly noisy environment, a novel addition of median filter before the GECCA algorithm is suggested for improving the accuracy of onslaught the EEG signal. The median filter is opted due to its edge preserving nature and speed. This proposed approach is appraised using efficacy grounds for instance Del signal to noise ratio, Lambda (λ), root mean square error and receiver operating characteristic (ROC) parameters and verified contrary to presently obtainable EEG artifacts exclusion methods. The primary concern is to improve the efficacy and precision of the proposed artifact elimination technique. The elapsed time is also calculated to evaluate the computation efficiency. Results show that the proposed algorithm is appropriate to be used as an addition to existing algorithms in use.

Kumar Shukla P., Kumar Shukla P., Sharma P., Rawat P., Samar J., Moriwal R., Kaur M.

A drug-drug interaction or drug synergy is extensively utilised for cancer treatment. However, prediction of drug-drug interaction is defined as an ill-posed problem, because manual testing is only implementable on small group of drugs. Predicting the drug-drug interaction score has been a popular research topic recently. Recently many machine learning models have proposed in the literature to predict the drug-drug interaction score efficiently. However, these models suffer from the over-fitting issue. Therefore, these models are not so-effective for predicting the drug-drug interaction score. In this work, an integrated convolutional mixture density recurrent neural network is proposed and implemented. The proposed model integrates convolutional neural networks, recurrent neural networks and mixture density networks. Extensive comparative analysis reveals that the proposed model significantly outperforms the competitive models.

Pathak Y., Shukla P.K., Arya K.V.

In December of 2019, a novel coronavirus (COVID-19) appeared in Wuhan city, China and has been reported in many countries with millions of people infected within only four months. Chest computed Tomography (CT) has proven to be a useful supplement to reverse transcription polymerase chain reaction (RT-PCR) and has been shown to have high sensitivity to diagnose this condition. Therefore, radiological examinations are becoming crucial in early examination of COVID-19 infection. Currently, CT findings have already been suggested as an important evidence for scientific examination of COVID-19 in Hubei, China. However, classification of patient from chest CT images is not an easy task. Therefore, in this paper, a deep bidirectional long short-term memory network with mixture density network (DBM) model is proposed. To tune the hyperparameters of the DBM model, a Memetic Adaptive Differential Evolution (MADE) algorithm is used. Extensive experiments are drawn by considering the benchmark chest-Computed Tomography (chest-CT) images datasets. Comparative analysis reveals that the proposed MADE-DBM model outperforms the competitive COVID-19 classification approaches in terms of various performance metrics. Therefore, the proposed MADE-DBM model can be used in real-time COVID-19 classification systems.

Singhai N.J., Maheshwari R., Ramteke S.

Triple-negative breast cancer requires high treatment specificity and efficacy due to its aggressive nature. In the present investigation, multi-walled carbon-nanotubes (MWCNTs) were functionalized using Hyaluronic acid (HA) and α-Tocopheryl succinate (α-TOS) and loaded with Doxorubicin (Dox) to obtained novel α-TOS-HA-MWCNTs/Dox conjugate to achieve enhanced cellular-placement and anticancer-therapeutic action against CD44 receptors overexpressing TNBC cells (MDA-MB-231). Interestingly, α-TOS-HA-MWCNTs/Dox displayed high cellular uptake as compared to individually tailored MWCNTs formulations. Anticancer investigation revealed prominent growth inhibition effect (SRB assay; GI50; 0.810 ± 0.017; p