Nesterov, Sergey V

Zakurdaeva O.A., Asachenko A.F., Topchiy M.A., Nesterov S.V.

The new extractant based on dicyclohexano-14-crown-4 solution in 1,1,7-trihydrododecafluoroheptanol is proposed for the removal of lithium cations from the chloride media, such as reservoir waters. The stereoisomerism of the macrocyclic ligand is revealed to be a key factor determining the efficiency and selectivity of this system.

Nesterov S.V., Rychkov P.V., Zakurdaeva O.A., Feldman V.I.

1,1,7-Trihydrododecafluoroheptanol is a promising solvent for the development of strontium-selective extractants based on individual stereoisomers of dicyclohexano-18-crown-6 (DCH18C6). In this study the distribution of DCH18C6 between organic and aqueous phases was determined and the effect of macrocycle stereoisomerism was revealed. Extractability of nitric acid depended on the acidity of initial aqueous phase and did not on DCH18C6 stereoisomerism. Based on the structure of radiolytic intermediates, the main channels of radiation destruction of the macrocycle and the solvent were proposed. The obtained data highlights the potentiality of the DCH18C6/1,1,7-trihydrododecafluoroheptanol for designing a technological process for the selective strontium extraction.

Zakurdaeva O.A., Kuchkina I.O., Kurkin T.S., Nesterov S.V.

Thermal stability of macrocyclic complexes with alkaline earth metal salts is of crucial importance for their applicability as the components of new electrolytes, ionic liquids and precursors in chemical vapor deposition processes. The complexes of 18-crown-6 and stereoisomeric dicyclohexano-18-crown-6 with alkaline earth metal halides were synthesized and studied by the combination of simultaneous DSC/TGA and FTIR-spectroscopy. The stability of these compounds depended on the size of the cation and anion as follows: Ba2+ < Sr2+ < Ca2+ and Cl− < Br− ≈ I−. The two-stage mechanism of destruction was found for the complexes with CaCl2, SrBr2, SrI2. This implies, most probably, the coexistence of two conformationally nonequivalent forms of the macrocycles with different thermal stability rather than the destruction of the macrocycle at high temperatures. The revealed trends, in our opinion, were caused by changes in the interaction energy between macrocycle and metal cation.

Nesterov S.V., Zakurdaeva O.A.

Modification of benzene rings in dibenzo-14-crown-4 by hydrogenation of a cyclohexane moiety or introduction of tert -butyl substituents leads to macrocycles superior to benzo-15-crown-5 in extraction of lithium salts from aqueous solutions and in resistance to leaching into the aqueous phase.

Nesterov S.V., Zakurdaeva O.A., Sokolova N.A., Rychkov P.V., Feldman V.I.

The complexes of 18-crown-6 with alkali-earth metal halides were synthesized to simulate the macrocyclic component of crown-containing extractants selective for radionuclide 90 Sr and to investigate the effect of cationic and anionic factors on its radiation destruction at low-temperature (77 K) irradiation. The halide anion was found to protect the complexes from ring opening at the initial stages of radiolysis due to positive charge transfer from the primary macrocyclic radical cation to anion. This effect was found in 18-crown-6 complexes with SrCl 2 , SrBr 2 and BaCl 2 , where the macrocycle had D 3d symmetry. In contrast, the anionic protection was less efficient when the 18-crown-6 conformation was measurably distorted, as illustrated by the examples of complexes with SrI 2 , CaCl 2 and, especially, MgCl 2 with folded C 2 and D 2 symmetries. Based on the results obtained, it was concluded that preliminary conformational analysis of a macrocyclic complex could be a useful way to predict its resistance to radiation-induced polyether ring cleavage. • Radiation stability of 18-crown-6 complexes depends on the nature of cation and anions. • Halide-anions protect macrocycle from radiation-induced destruction. • Decrease in metal cation size promotes ring opening at early stage of radiolysis. • Distortion of macrocycle symmetry increases the degradation of the complex.

Nesterov S.V., Zakurdaeva O.A., Sokolova N.A., Rychkov P.V., Feldman V.I.

Nesterov P.V., Shilovskikh V.V., Sokolov A.D., Gurzhiy V.V., Novikov A.S., Timralieva A.A., Belogub E.V., Kondratyuk N.D., Orekhov N.D., Skorb E.V.

Supramolecular organic systems can be used as a host for the encapsulation of small organic molecules. Here, we chose melamine barbiturate as a robust system capable of supramolecular assembly and the Rhodamine 6G dye entrapment as a guest molecule. The encapsulation of the dye was investigated by UV-visible spectroscopy, SEM and optical fluorescent microscopy while the insight into the crystal structure of the system was obtained by single crystal and powder XRD. For investigation of the system’s properties on a molecular level, the DFT and Classical Molecular Dynamics methods were utilized. Surprisingly, both theoretical and experimental data show not only the successful encapsulation of Rhodamine 6G molecules inside the supramolecular assembly, but also that inclusion of such molecules leads to the drastic improvement in the organic crystal shape. The melamine barbiturate in presence of the Rhodamine 6G molecules tend to form crystals with lesser degree of twinning and higher symmetry in shape than the ones without dye molecules.

Nesterov S.V., Zakurdaeva O.A.

The contact of crown ether/ionic liquid extractants with nitric acid solutions results in macrocycle protonation, which complicates the radiolysis mechanism and increases the radiation destruction of the system. This trend is caused by the scavenging of secondary electrons by H3O+ ions at the early stages of the process. The revealed channel of the radiation-chemical transformations was not taken into account in the previous models of testing the radiation resistance of crown-containing compositions designed for 90Sr removal from radioactive wastes.

Nesterov S.V., Zakurdaeva O.A., Sokolova N.A., Rychkov P.V., Feldman V.I.

Abstract Macrocyclic 18-crown-6⋅SrCl2 and 18-crown-6⋅YCl3⋅4.25H2O complexes were synthesized, characterized by FTIR and DSC/TGA analysis and exposed to X-rays irradiation to study their resistance to polyether ring cleavage at early radiolysis stages by using EPR spectroscopy. Yttrium complex was found to be less stable in comparison with that of strontium as evidenced by a higher fraction of acyclic radicals resulted from the macrocycle destruction. An analysis of conformationally sensitive regions of FTIR spectra of 18-crown-6⋅YCl3⋅4.25H2O points to the strong distortion of the macrocycle symmetry that is one of the probable factors affecting the radiolytic cleavage of the polyether ring. The results obtained in the present study contribute to theoretical framework required to develop a radiation stable macrocyclic extractant for separation of the Sr/Y radionuclides.

Nesterov S.V., Zakurdaeva O.A., Kochetkova M.A., Kuchkina I.O.

To study the radiolysis of the extractant composition based on solutions of dicyclohexano-18-crown-6 (DCH18C6) in ionic liquids containing the bis(trifluoromethylsulfonyl)imide anion (NTf2−), we synthesized stereoisomeric DCH18C6•Sr(NTf2)2 complexes as a model of the strontium-containing macrocyclic component of this system and studied the mechanism of their destruction in the solid phase. Three main stages of radiation-chemical transformations were found. At the initial stage of radiolysis after ionization of the complex components, a positive charge is transferred from the macrocycle to the anion, which is induced by the lower ionization potential of NTf2− as compared to the crown ether. This results in the radiation protection of the macrocycle due to the blockage of the polyether ring cleavage, which is observed under radiolysis of “free” DCH18C6. The next stage consists in the accumulation of the —O—•CH—CH2— radicals caused by the reaction of the dissociation products of the NTf2− anion with the crown ether. It intensifies the radiation destruction of the polyether ring. At the final stage, the macrocyclic radicals efficiently scavenge SO2, the molecular product of dissociation of the NTf2− anion, with the formation of sulfonyl-type radicals. The discovered channels of radiation-chemical transformations of the macrocycle in the systems including the NTf2− anion should be considered in the design of new radiation-resistant extractants.

Loutchkina I., Jain L.C., Nguyen T., Nesterov S.

This paper presents an approach for modelling Systems Integration Technical Risks SITR assessment using Bayesian Belief Networks BBN. SITR represent a significant part of project risks associated with a development of large software intensive systems. We propose conceptual modelling framework to address the problem of SITR assessment at early stages of a system life cycle. This framework includes a set of BBN models, representing the risk contributing factors, and complementing Parametric Models PM, used for providing input data to the BBN models. In particular we describe SITR identification approach explaining corresponding BBN models' topologies and relevant conceptual model framework. This framework includes a set of BBN models, representing the risk contributing factors, fused with complementary PMs providing input data to the BBN models. Heuristic approaches for easing Conditional Probabilities Tables CPT generation are described. We briefly discuss preliminary results of model testing. In conclusion we summarise benefits and constraints for SITR assessment based on BBN models, and provide suggestions for further research directions for model improvement.

Nesterov S.V., Zakurdaeva O.A., Sokolova N.A., Rudakova T.A., Feldman V.I.

Abstract Effects of cation size on relative yields of macrocycle cleavage under irradiation of stereoisomeric dicyclohexano-18-crown-6 complexes with alkaline earth metal chlorides were studied to mimic the radiolysis of the macrocyclic components of metal-loaded extractants applicable for radioactive waste reprocessing. Chloride-anions was found to prevent the macrocycle from destruction at early stage of radiolysis. However, radiolytic atomic chlorine was generated as a result of anion decay that promoted radiation-chemical transformations of the crown ether in secondary radical reactions. Interaction of metal cation with donor oxygen atoms of crown ether led to conformational rearrangement of the macrocycle and induced additional channel of C–O bond cleavage at post-radiation stages of radiolysis. Total fraction of acyclic radical products increased as follows: Ca2+ > Sr2+ > Ba2+. This sequence order is correlated with data of vibrational spectroscopy and implies more radiation sensitivity of the folded, asymmetric conformation of macrocycle in complexes with calcium chloride in contrast to symmetric complexes with barium chloride.

Sharsheeva A., Iglin V.A., Nesterov P.V., Kuchur O.A., Garifullina E., Hey-Hawkins E., Ulasevich S.A., Skorb E.V., Vinogradov A.V., Morozov M.I.

A model nanocomposite releases drug within 40 minutes under UV irradiation.

Zverovshchikov A., Zverovshchikov V., Nesterov S.

The results of the system analysis of the set of input factors of the volumetric centrifugal-planetary processing, allowing to implement a comprehensive approach to the provision of quality processing parameters, are considered. A sequence of modeling processes ensuring the quality of surfaces during bulk processing is given. The results of modeling the contact of an abrasive working body with the surface of a workpiece with a microrelief are shown. The factors determining the stability of reliable achievement of qualitative indicators are noted. A dependence has been developed to determine the parameter of the surface roughness to be reduced, based on the results of modeling the contact between the surfaces of the working fluid and the workpiece by the finite element method. The experience of designing volumetric centrifugal processing operations on the basis of modeling is generalized. Methodical methods of technological preparation of manufacture for volumetric processing are offered.

Nesterov S.V., Zakurdaeva O.A., Kurkin T.S., Feldman V.I.

Complexes of 18-crown-6 with BaCl2, Ba(NO3)2 and Ba(NTf2)2 salts were synthesized and irradiated with X-rays to simulate the radiation degradation of a macrocyclic component of extractants based on crown ether solutions in commonly used solvents. Structures and post-irradiation transformations of radical products stabilized in these complexes at 77 K were studied using EPR spectroscopy, and the mechanism of their formation and decay was proposed. Differences in ionization potentials of the macrocycle and the anions and reactivity of the intermediates generated from the anions are of importance for radiation stability of the studied compounds. The nitrate-anions was demonstrated to protect 18C6 from destruction whereas Cl− and bis(trifluoromethylsulfonyl)imide-anions can impair the radiation stability of the macrocycle. The results of the present study offer an opportunity to predict the radiation stability of the crown ether extractants and their applicability for liquid radioactive waste reprocessing.

Timralieva A.A., Chumakova N.A., Fionov A.V., Konstantinova E.A., Zaripov R.B., Demekhin M.A., Radchenko M.E., Novikov A.S., Travin S.O., Kokorin A.I., Skorb E.V.

Altaf Nazir M., Ullah S., Umar Shahid M., Hossain I., Najam T., Abdelmotaleb M.A., ur Rehman A., Rezaul Karim M., Shoaib Ahmad Shah S.

Zakurdaeva O.A., Asachenko A.F., Topchiy M.A., Nesterov S.V.

The new extractant based on dicyclohexano-14-crown-4 solution in 1,1,7-trihydrododecafluoroheptanol is proposed for the removal of lithium cations from the chloride media, such as reservoir waters. The stereoisomerism of the macrocyclic ligand is revealed to be a key factor determining the efficiency and selectivity of this system.

Robla J.I., Alcaraz L., Alguacil F.J.

Not having the same grade of popularity as other metals like rare earth elements, gold, copper, etc., strontium is a chemical element with wide uses in daily life, which is why it appears in the EU 2023 list of Critical Raw Materials. Among the sources (with celestine serving as the raw material) used to recover the element, the recycling of some Sr-bearing secondary wastes is under consideration, and it is also worth mentioning the interest in the removal of strontium from radioactive effluents. To reach these goals, several technological alternatives are being proposed, with the most widely used being the adsorption of strontium or one of its isotopes on solid materials. The present work reviews the most recent advances (for 2024) in the utilization of diverse technologies, including leaching, adsorption, liquid–liquid extraction, etc., in the recovery/elimination of Sr(II) and common 90Sr and 85Sr radionuclides present in different solid or liquid wastes. While adsorption and membrane technologies are useful for treating Sr-diluted solutions (in the mg/L order), liquid–liquid extraction is more suitable for the treatment of Sr-concentrated solutions (in the g/L order).

Bakhrushina E.O., Belyavsky N.O., Kuzina V.N., Khodenok A.I., Demina N.B., Ramenskaya G.V.

Introduction. One example of new polymers for target delivery systems are zeolites (ZEO) and zeolite imidazole frameworks (ZIF). ZEO are actively used in industry, ecology, pharmacy and biomedicine, having high porosity, adsorption capacity and physico-chemical stability. ZIF, as a type of metal-organic framework, are characterized by high thermal and chemical resistance, biocompatibility and adjustable porosity, which makes them promising for drug delivery. Both polymers, due to their properties, open up new opportunities for the creation of targeted drugs with prolonged action and minimal side effects. The purpose of this review is to characterize ZEO and ZIF as promising polymers for targeted delivery systems and to consider their basic properties.Text. The article discusses the structure and methods of analysis of zeolites and zeolite imidazole frameworks, methods of their synthesis, mechanism of action, and applications of polymers as directed delivery systems.Conclusion. The review shows that the chemical and physical properties of ZEO and ZIF polymers make it possible to develop effective targeted drug delivery systems used in oncology, ophthalmology, dentistry and orthopedics. Low cytotoxicity, regulated polymer pore loading and the effectiveness of intracellular targeting confirm the prospects of using ZEO and ZIF in medicine.

Sahu K.P., Singh S., Singh A.K., Azad U.P., Yadav D., Kumar V., Singh S.K.

Li B., Gao Q., Wu Y., Lei H., Ma S., Wang W., Sun H., Ma W., Zheng J., Yuan C., Zhang Y., Jia Y., Ma F., Gu Q., Sang S., et. al.

Normatov S., Nesterov P.V., Aliev T.A., Timralieva A.A., Novikov A.S., Skorb E.V.

Song D., Li H.

As the research on drug delivery systems continues to improve, the use of carbon nanomaterials in drug delivery is becoming more and more widespread, but there are limitations to the use of carbon nanomaterials alone in drug systems, so the use of nano-polymers in combination with carbon nanomaterials is more conducive to the use of drug delivery, which in the area of drug delivery is mainly used in the field of anticancer therapy, topical therapies, and the treatment of infectious diseases, and so on.

Himawan A., Korelidou A., Pérez-Moreno A.M., Paris J.L., Domínguez-Robles J., Vora L.K., Permana A.D., Larrañeta E., Graham R., Scott C.J., Donnelly R.

This study explores the formulation and characterization of poly(vinyl alcohol) (PVA)-based composite hydrogels synthesized through solid-state crosslinking. Comprehensive assessments were conducted on their physicochemical properties, leachables, and immunogenicity. Swelling experiments...

Atkinson C., Welch G.C.

With an increased demand for lithium ion (Li-ion) battery technologies, and the small number of lithium mines around the globe, there has been a heightened desire to develop new materials capable of extracting lithium from aqueous sources such as the ocean. To do so in an economically viable way, the materials must be highly selective toward the extraction of Li-ions so as not to necessitate the further purification from competing metal ions such as magnesium, sodium, or calcium. To address this, herein we report on three new conjugated imide compounds functionalized with the crown ether benzo-9-crown-3. The three new compounds Phth-CE, F-Phth-CE, and NMI-CE were synthesized via atom-economical condensation reactions between an amino functionalized benzo-9-crown-3 with commodity aryl imide building blocks. These three new compounds serve to develop an understanding of Li-ion capture via the benzo-9-crown-3 moieties scaffolded onto stable aromatic ring systems. The nodal plane between the aryl imide and the phenyl ring of benzo-9-crown-3 isolates the crown ether allowing for unhindered Li-ion capture and release. Subtle derivatization of the aryl imide showcases structural versatility to include a fluoride amenable to nucleophilic aromatic substitution and/or to act as a diagnostic handle and naphthalene unit extending optical absorption to longer wavelengths. Each new compound exhibits the formation of Li-ion sandwich complexes as determined by 7Li NMR spectroscopy, and near identical Li-ion extraction efficiencies, distribution coefficients, and selectivity under acidic conditions in neat and mixed-metal ion solutions as determined by triple quadrupole inductively coupled plasma mass spectrometry analysis.

Alshamsi H.A., Jabir F.A.

Jiang F., Li Q., Li Y., Lai X., Duan Y., McDowell A., Huang Z., Liu S., Wang Y., Zhang C., Qu Y., Pan X.

In biomedicine, one of the major challenges is effectively promoting wound healing of bacterial infections. Current wound dressings (e.g., gauze and bandages) are far from meeting the needs of the population as they lack various bioactivities to promote wound healing (including hemostasis, antimicrobial, anti-inflammatory, promotion of tissue regeneration, etc.) and are not biodegradable. In this study, we prepared an insect chitosan/pullulan/citric acid three-dimensional, layered electrospun nanofiber sponge embedded with ZnMOF in situ (3D-ZnMOF) and used it to promote MRSA-infected wound healing. The fabrication method and physicochemical characteristics of 2D nanofiber membranes and 3D nanofiber sponges were thoroughly assessed. SEM-EDS, XPS, XRD, and FT-IR were used to characterize the 3D-ZnMOF sponges, and the release behavior of zinc ions was examined. Experiments conducted both in vitro and in vivo demonstrated the hemostatic characteristics, biocompatibility, and antibacterial activity of 3D-ZnMOF sponges. 3D-ZnMOF sponges showed the ability to promote wound contraction, accelerate collagen deposition, inhibit inflammatory factors, and promote angiogenesis in an MRSA-infected rat whole-skin wound model. Consequently, 3D-ZnMOF nanofiber sponges offer a great deal of promise for accelerating the healing of wounds infected with drug-resistant bacteria.

Pallavi P., Girigoswami K., Gowtham P., Harini K., Thirumalai A., Girigoswami A.

aims: To formulate nanoencapsulated photosensitizers for effective photodynamic therapy. background: As cancer therapy progresses, challenges remain due to the inherent drawbacks of conventional treatments such as chemotherapy, gene therapy, radiation therapy, and surgical removal. Due to their associated side effects, conventional treatments affect both cancerous and normal cells, making photodynamic therapy (PDT) an attractive alternative. objective: As a result of its minimal toxicity, exceptional specificity, and non-invasive characteristics, PDT represents an innovative and highly promising cancer treatment strategy using photosensitizers (PSs) and precise wavelength excitation light to introduce reactive oxygen species (ROS) in the vicinity of cancer cells. method: Poor aqueous solubility and decreased sensitivity of Rhodamine 6G (R6G) prevent its use as a photosensitizer in PDT, necessitating the development of oxidized sodium alginate (OSA) hydrogelated nanocarriers to enhance its bioavailability, targeted distribution, and ROS-quantum yield. result: The ROS quantum yield increased from 0.30 in an aqueous environment to 0.51 when using an alginate-based formulation, and it was further enhanced to 0.81 in the case of OSA. Furthermore, the nanoformulation produced fluorescent signals suitable for use as cellular imaging agents, demonstrating contrast-enhancing capabilities in medical imaging and showing minimal toxicity. conclusion: It can be concluded that the synthesized OSA-R6G nanoformulation has the potential to be used in photodynamic therapy as a photosensitizer in the treatment of cancer and can also be utilized for clinical theranostic applications. other: NA

Sosulin I.S., Lisouskaya A.

Kanagasundaram T., Murphy O., Haji M.N., Wilson J.J.

Lithium, the lightest alkali metal, has been called the "new white gold" because of its limited availability and critical importance in arising applications in clean energy, like hybrid and electric vehicles. However, the rapidly growing demand for lithium, combined with its low global production rates, has led to concerns regarding the development of new technologies that require this critical mineral. For this reason, there is a need for cost-effective, energy-efficient, and environmentally friendly approaches to isolate lithium from sustainable resources like brine, ores, and seawater. In this context, solvent extraction is a promising technique for lithium recovery from these sources that has advantages over other approaches like precipitation, solid-state adsorption, and membranes. However, there are few processes in industry that use solvent extraction for lithium extraction and purification. The scarce use of this method industrially is possibly a consequence of critical knowledge gaps that need to be addressed prior to the optimization of processes with suitably high lithium selectivity and extraction efficiency. This review bridges these gaps by highlighting the coordination chemistry of lithium and discussing the requirements for developing highly selective lithium chelators for solvent extraction. Additionally, the lithium coordination properties and solvent extraction performance of macrocyclic and acyclic chelator classes, as well as ionic liquid extraction systems, used to extract lithium from artificial solutions, brines, and seawater are reviewed.

Nesterov S.V., Rychkov P.V., Zakurdaeva O.A., Feldman V.I.

1,1,7-Trihydrododecafluoroheptanol is a promising solvent for the development of strontium-selective extractants based on individual stereoisomers of dicyclohexano-18-crown-6 (DCH18C6). In this study the distribution of DCH18C6 between organic and aqueous phases was determined and the effect of macrocycle stereoisomerism was revealed. Extractability of nitric acid depended on the acidity of initial aqueous phase and did not on DCH18C6 stereoisomerism. Based on the structure of radiolytic intermediates, the main channels of radiation destruction of the macrocycle and the solvent were proposed. The obtained data highlights the potentiality of the DCH18C6/1,1,7-trihydrododecafluoroheptanol for designing a technological process for the selective strontium extraction.

Khatoon R., Raksasat R., Ho Y.C., Lim J.W., Jumbri K., Ho C., Chan Y.J., Abdelfattah E.A., Khoo K.S.

The global demand for lithium, which is indispensable for electric cars and electrical devices, has increased. Lithium recovery from oilfield-produced water is necessary to meet the growing need for lithium-ion batteries, protect the environment, optimize resource utilization, and cut costs to ensure a successful energy transition. It is useful for keeping water supplies in good condition, adhering to legal requirements, and making the most of technological advances. Oil and gas companies might see an increase in revenue gained through the lithium extraction from generated water due to the recouping of energy costs. Therefore, this review focuses on contamination and treatment strategies for the oilfield-produced water. It includes a discussion of the global lithium trade, a financial analysis of lithium extraction, and a comparison of the various methods currently in use for lithium extraction. It was evaluated that economic considerations should be given priority when selecting environmentally friendly methods for lithium recovery from oilfield-produced water, and hybrid methods, such as adsorption–precipitation systems, may show promising results in this regard. Lastly, future prospects for the lithium industry were also discussed.

Liu Q., Yang P., Tu W., Sun H., Li S., Zhang Y.

The rapid development of the new energy industry has increased the demand and prices of lithium, which has in turn promoted the development of lithium resources. Lithium recovery from oil and gas field produced water (OGPW) is a potential path to obtain lithium. However, this method is not widely utilized in industrialization due to various factors such as interference, immature processes, and low economic viability. This research aims to explore the technology and application of lithium recovery from OGPW. This review focuses on the output, characteristics, and lithium concentration of OGPW in the main basins of China to assess the feasibility of lithium recovery. Additionally, the common technologies for lithium recovery in OGPW are summarized and compared. The proposal suggests that combining different processes can leverage the advantages of individual technologies and enhance the efficiency of lithium recovery. Furthermore, the major challenges related to these technologies in terms of cost and technology are discussed. The conclusion highlights the importance of conducting research on combination technologies, specifically the pretreatment+ enrichment (adsorption/extraction-membrane separation) + precipitation process. It also highlights the potential benefits of integrating lithium recovery with OGPW treatment to reduce overall treatment costs through the recovery and sale of lithium.

González-Flores E., Zambudio N., Pardo-Moreno P., Gonzalez-Astorga B., de la Rúa J.R., Triviño-Ibáñez E.M., Navarro P., Espinoza-Cámac N., Casado M.Á., Rodríguez-Fernández A.

Abstract Purpose Strategies for the treatment of liver metastases from colon cancer (lmCRC) are constantly evolving. Radioembolization with yttrium 90 (Y-90 TARE) has made significant advancements in treating liver tumors and is now considered a potential option allowing for future resection. This study reviewed the scientific evidence and developed recommendations for using Y-90 TARE as a treatment strategy for patients with unresectable lmCRC. Methods A multidisciplinary scientific committee, consisting of experts in medical oncology, hepatobiliary surgery, radiology, and nuclear medicine, all with extensive experience in treating patients with ImCRC with Y-90 TARE, led this project. The committee established the criteria for conducting a comprehensive literature review on Y-90 TARE in the treatment of lmCRC. The data extraction process involved addressing initial preliminary inquiries, which were consolidated into a final set of questions. Results This review offers recommendations for treating patients with lmCRC using Y-90 TARE, addressing four areas covering ten common questions: 1) General issues (multidisciplinary tumor committee, indications for treatment, contraindications); 2) Previous process (predictive biomarkers for patient selection, preintervention tests, published evidence); 3) Procedure (standard procedure); and 4) Post-intervention follow-up (potential toxicity and its management, parameters for evaluation, quality of life). Conclusions Based on the insights of the multidisciplinary committee, this document offers a comprehensive overview of the technical aspects involved in the management of Y-90 TARE. It synthesizes recommendations for applying Y-90 TARE across various phases of the treatment process.

Zakurdaeva O.A., Kuchkina I.O., Kurkin T.S., Nesterov S.V.

Thermal stability of macrocyclic complexes with alkaline earth metal salts is of crucial importance for their applicability as the components of new electrolytes, ionic liquids and precursors in chemical vapor deposition processes. The complexes of 18-crown-6 and stereoisomeric dicyclohexano-18-crown-6 with alkaline earth metal halides were synthesized and studied by the combination of simultaneous DSC/TGA and FTIR-spectroscopy. The stability of these compounds depended on the size of the cation and anion as follows: Ba2+ < Sr2+ < Ca2+ and Cl− < Br− ≈ I−. The two-stage mechanism of destruction was found for the complexes with CaCl2, SrBr2, SrI2. This implies, most probably, the coexistence of two conformationally nonequivalent forms of the macrocycles with different thermal stability rather than the destruction of the macrocycle at high temperatures. The revealed trends, in our opinion, were caused by changes in the interaction energy between macrocycle and metal cation.

Koshcheeva A.M., Rodin A.V., Anan’ev A.V.

The processes of solvent extraction of cesium and strontium stable isotopes using solutions of macrocyclic polyethers in organic solvents from nitric acid solutions were studied. The influence of crown ether structure and solvent type on the distribution coefficients of cesium (DCs) and strontium (DSr) was investigated. Extraction systems for the co-extraction of cesium and strontium were tested, in which 1,1,7-trihydrododecafluoroheptanol and chlorine-substituted hydrocarbons were used as solvents. It was shown that there are highest DCs and DSr during co-extraction of metals when using a mixture of DTBDB18C6 and DCH18C6. Experimental data prove high selectivity of crown ethers for the extraction of cesium and strontium into a separate fraction when managing radioactive waste.

Butylskii Dmitrii Yu., Dammak Lasâad, Larchet Christian, Pismenskaya Natalia D., Nikonenko Victor V.

In recent years, due to the sharp increase in lithium demand, the interest in the problem of lithium recovery/extraction has increased dramatically: according to the Scopus database, about 3000 scientific publications on this issue appeared in 2021. The efforts of many specialists are directed towards the development of new, more economical and environmentally safe membrane technologies for lithium recovery to replace the existing reagent-based methods. This review integrates up-to-date data about the traditional and prospective methods for lithium recovery from natural solutions and leachates resulting from the disposal of spent batteries. The attention is focused on membrane methods. Known approaches are classified and analyzed, experimental and theoretical aspects of membrane-based ion separation are described; separation mechanisms and mathematical models are discussed. The review addresses pressure-driven and electromembrane processes, relatively well-developed at a laboratory level, which are used to extract lithium and other singly charged ions from mixed solutions containing large amounts of magnesium and calcium. The results of application of commercial and laboratory-made membranes are compared. Novel and emerging approaches suitable for effective separation of lithium ions from a mixture of singly charged cations, including hybrid electrobaromembrane methods, are considered.The bibliography includes 295 references

Arabzadeh H., Walker B., Sperling J.M., Acevedo O., Ren P., Yang W., Albrecht-Schönzart T.E.

Shirasaki K., Nagai M., Nakase M., Tabata C., Sunaga A., Yaita T., Yamamura T.

The solvent extraction of Sr(ii) was carried out using DCH18C6, and two HFC mixed solvents composed of organic solvents and HFC-43 (HFC-43: 1,1,1,2,2,3,4,5,5,5-decafluoropentane), and two acids (nitric acid and H2PFTOUD).

Nesterov S.V., Zakurdaeva O.A.

Modification of benzene rings in dibenzo-14-crown-4 by hydrogenation of a cyclohexane moiety or introduction of tert -butyl substituents leads to macrocycles superior to benzo-15-crown-5 in extraction of lithium salts from aqueous solutions and in resistance to leaching into the aqueous phase.

Miao Q., Sun T., Chen H., Zheng Q., Duan W., Wang J., Chen J.

Pochekutova T.S., Fukin G.K., Baranov E.V., Petrov B.I., Lazarev N.M., Khamylov V.K.

• The new barium β-diketonate complexes with 18-crown-6 were synthesized. • The thermal properties and structures of these complexes have been studied. • The topological characteristics of the electron density in them have been investigated. • The enthalpy of sublimation of [Ba(adtfa) 2 (18-crown-6)] was measured by Knudsen method and evaluated through the energy of intermolecular interactions. • The barium complexes were found to differ by the arrangement of the CF 3 and Ad substituents in the coordination sphere. The new barium β-diketonate complexes with 18-crown-6 [Ba(adtfa) 2 (18-crown-6)] ( 1 ) and [Ba(adtfa) 2 (18-crown-6)](CDCl 3 ) 2 ( 2 ) (adtfa = 1,1,1-trifluoro-4-(1-adamantyl)-2,4-butanedionato, 18-crown-6 = 1,4,7,10,13,16-hexaoxacycloocta-decane) were synthesized and characterized by elemental analysis, IR-, 1 H NMR-spectroscopy and X-ray diffraction analysis. The mutual arrangement of the β-diketonate ligands relative to the barium atoms in 1 and 2 was found to be different. The nature of chemical interactions and charges distribution in 1 and 2 was investigated using an experimental-theoretical approach based on crystal (asymmetric unit–cell aspherical scattering factor) and molecular (whole–molecule aspherical scattering factor) invarioms within the framework of Bader theory. It was shown that the less favorable conformation of complex 2 is stabilized in the crystal by the higher energy of intermolecular interactions as compared to 1 . The energy of intermolecular interactions (94.3 kJ/mol) in 1 was estimated by electron density topological analysis and agrees well with the experimentally obtained sublimation enthalpy (83.2 ± 1.1 kJ/mol).

Orekhov N., Kondratyuk N., Logunov M., Timralieva A., Shilovskikh V., Skorb E.V.

On the basis of computational and experimental approaches, we provide molecular-level insights into melamine cyanurate (M-CA) self-assembly in aqueous solution and identify corresponding mechanisms...