Utility of Pickering emulsions in improved oral drug delivery
Zongguang Tai
1, 2
,
Yanping Huang
3
,
Quangang Zhu
3
,
Wei Wu
1, 4
,
Tao Yi
5
,
Zhongjian Chen
3
,
Yi Lu
1, 6
Publication type: Journal Article
Publication date: 2020-11-01
scimago Q1
wos Q1
SJR: 1.742
CiteScore: 16.0
Impact factor: 7.5
ISSN: 13596446, 18785832
PubMed ID:
32949702
Drug Discovery
Pharmacology
Abstract
• Properties of particle stabilizers are crucial to construct Pickering emulsions. • Pickering emulsions enhance bioavailability or bioaccessibility of drugs. • Controllable release and high stability relate to the interfacial particles. • Digestion can be tailored by tuning the properties of the particle stabilizers. Pickering emulsions are surfactant-free emulsions stabilized by solid particles. Their unique structure endows them with good stability, excellent biocompatibility, and environmental friendliness. Pickering emulsions have displayed great potential in oral drug delivery. Several-fold increases in the oral bioavailability or bioaccessibility of poorly soluble drugs, such as curcumin, silybin, puerarin, and rutin, were achieved by using Pickering emulsions, whereas controlled release was found for indomethacin and caffeine. The shell of the interfacial particle stabilizers provides enhanced gastrointestinal stability to the cargos in the oil core. Here, we also discuss general considerations concerning particle stabilizers and design strategies to control lipid digestion.
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Metrics
82
Total citations:
82
Citations from 2024:
42
(51.22%)
The most citing journal
Citations in journal:
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GOST
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Tai Z. et al. Utility of Pickering emulsions in improved oral drug delivery // Drug Discovery Today. 2020. Vol. 25. No. 11. pp. 2038-2045.
GOST all authors (up to 50)
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Tai Z., Huang Y., Zhu Q., Wu W., Yi T., Chen Z., Lu Y. Utility of Pickering emulsions in improved oral drug delivery // Drug Discovery Today. 2020. Vol. 25. No. 11. pp. 2038-2045.
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RIS
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TY - JOUR
DO - 10.1016/j.drudis.2020.09.012
UR - https://doi.org/10.1016/j.drudis.2020.09.012
TI - Utility of Pickering emulsions in improved oral drug delivery
T2 - Drug Discovery Today
AU - Tai, Zongguang
AU - Huang, Yanping
AU - Zhu, Quangang
AU - Wu, Wei
AU - Yi, Tao
AU - Chen, Zhongjian
AU - Lu, Yi
PY - 2020
DA - 2020/11/01
PB - Elsevier
SP - 2038-2045
IS - 11
VL - 25
PMID - 32949702
SN - 1359-6446
SN - 1878-5832
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Tai,
author = {Zongguang Tai and Yanping Huang and Quangang Zhu and Wei Wu and Tao Yi and Zhongjian Chen and Yi Lu},
title = {Utility of Pickering emulsions in improved oral drug delivery},
journal = {Drug Discovery Today},
year = {2020},
volume = {25},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.drudis.2020.09.012},
number = {11},
pages = {2038--2045},
doi = {10.1016/j.drudis.2020.09.012}
}
Cite this
MLA
Copy
Tai, Zongguang, et al. “Utility of Pickering emulsions in improved oral drug delivery.” Drug Discovery Today, vol. 25, no. 11, Nov. 2020, pp. 2038-2045. https://doi.org/10.1016/j.drudis.2020.09.012.