Open Access
d -α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity
Monica Teixeira
1
,
Patrícia Severino
2
,
T Andreani
3
,
Prapaporn Boonme
4
,
Amélia M. Silva
3
,
A. Santini
5
2
Publication type: Journal Article
Publication date: 2017-02-01
scimago Q2
wos Q2
SJR: 0.677
CiteScore: 5.8
Impact factor: 3.4
ISSN: 13190164, 22137475
PubMed ID:
28344473
Pharmacology
Pharmaceutical Science
Abstract
The aim of this study was the assessment of the physicochemical stability of d-α-tocopherol formulated in medium chain triglyceride nanoemulsions, stabilized with Tween®80 and Lipoid®S75 as surfactant and co-surfactant, respectively. d-α-tocopherol was selected as active ingredient because of its well-recognized interesting anti-oxidant properties (such as radical scavenger) for food and pharmaceutical industries. A series of nanoemulsions of mean droplet size below 90 nm (polydispersity index < 0.15) have been produced by high-pressure homogenization, and their surface electrical charge (zeta potential), pH, surface tension, osmolarity, and rheological behavior, were characterized as a function of the d-α-tocopherol loading. In vitro studies in Caco-2 cell lines confirmed the safety profile of the developed nanoemulsions with percentage of cell viability above 90% for all formulations.
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59
Total citations:
59
Citations from 2024:
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(23.72%)
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GOST
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Teixeira M. et al. d -α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity // Saudi Pharmaceutical Journal. 2017. Vol. 25. No. 2. pp. 231-235.
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Teixeira M., Severino P., Andreani T., Boonme P., Silva A. M., Santini A. d -α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity // Saudi Pharmaceutical Journal. 2017. Vol. 25. No. 2. pp. 231-235.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.jsps.2016.06.004
UR - https://doi.org/10.1016/j.jsps.2016.06.004
TI - d -α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity
T2 - Saudi Pharmaceutical Journal
AU - Teixeira, Monica
AU - Severino, Patrícia
AU - Andreani, T
AU - Boonme, Prapaporn
AU - Silva, Amélia M.
AU - Santini, A.
PY - 2017
DA - 2017/02/01
PB - King Saud University
SP - 231-235
IS - 2
VL - 25
PMID - 28344473
SN - 1319-0164
SN - 2213-7475
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Teixeira,
author = {Monica Teixeira and Patrícia Severino and T Andreani and Prapaporn Boonme and Amélia M. Silva and A. Santini},
title = {d -α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity},
journal = {Saudi Pharmaceutical Journal},
year = {2017},
volume = {25},
publisher = {King Saud University},
month = {feb},
url = {https://doi.org/10.1016/j.jsps.2016.06.004},
number = {2},
pages = {231--235},
doi = {10.1016/j.jsps.2016.06.004}
}
Cite this
MLA
Copy
Teixeira, Monica, et al. “d -α-tocopherol nanoemulsions: Size properties, rheological behavior, surface tension, osmolarity and cytotoxicity.” Saudi Pharmaceutical Journal, vol. 25, no. 2, Feb. 2017, pp. 231-235. https://doi.org/10.1016/j.jsps.2016.06.004.