Springer Nature
Bulletin of Experimental Biology and Medicine
,  том 164 ,  издание 5 ,  страницы 666-672

Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro

Тип публикации: Journal Article
Дата публикации: 2018-03-25
Springer Nature
RSCI
SCImago Q3
WOS Q4
БС1
SJR: 0.267
CiteScore: 1.4
Impact factor: 0.7
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Краткое описание
Antitumor efficiency of fascaplysin synthetic derivatives (7-phenylfascaplysin, 3-chlorofascaplysin, 3-bromofascaplysin, and 10-bromofascaplysin) was compared out in vitro on C6 glioma cells. The cytotoxic efficiency of all tested compounds was higher than that of unsubstituted fascaplysin; 3-bromofascaplysin and 7-phenylfascaplysin exhibited the best capacity to kill glioma C6 cells. Apoptosis was the main mechanism of glioma cell death. The cytotoxic activity of these compounds increased with prolongation of exposure to the substance and increase of its concentration. Fascaplysin derivatives modified all phases of glioma cell vital cycle. The count of viable tumor cell in G0 phase remained minimum by the end of experiment under the effects of 3-bromofascaplysin and 7-phenylfascaplysin.
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Lyakhova I. A. et al. Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro // Bulletin of Experimental Biology and Medicine. 2018. Vol. 164. No. 5. pp. 666-672.
ГОСТ со всеми авторами (до 50) Скопировать
Lyakhova I. A., Bryukhovetsky I. S., Kudryavtsev I. V., Khotimchenko Yu. S., Zhidkov M. E., Kantemirov A. V. Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro // Bulletin of Experimental Biology and Medicine. 2018. Vol. 164. No. 5. pp. 666-672.
RIS |
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TY - JOUR
DO - 10.1007/s10517-018-4055-4
UR - https://doi.org/10.1007/s10517-018-4055-4
TI - Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro
T2 - Bulletin of Experimental Biology and Medicine
AU - Lyakhova, I A
AU - Bryukhovetsky, I S
AU - Kudryavtsev, I. V.
AU - Khotimchenko, Yu S
AU - Zhidkov, M E
AU - Kantemirov, A V
PY - 2018
DA - 2018/03/25
PB - Springer Nature
SP - 666-672
IS - 5
VL - 164
PMID - 29577186
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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@article{2018_Lyakhova,
author = {I A Lyakhova and I S Bryukhovetsky and I. V. Kudryavtsev and Yu S Khotimchenko and M E Zhidkov and A V Kantemirov},
title = {Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2018},
volume = {164},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1007/s10517-018-4055-4},
number = {5},
pages = {666--672},
doi = {10.1007/s10517-018-4055-4}
}
MLA
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Lyakhova, I. A., et al. “Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro.” Bulletin of Experimental Biology and Medicine, vol. 164, no. 5, Mar. 2018, pp. 666-672. https://doi.org/10.1007/s10517-018-4055-4.
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