Bulletin of Experimental Biology and Medicine, volume 164, issue 5, pages 666-672
Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro
Lyakhova I A
1
,
Bryukhovetsky I S
1, 2
,
Kudryavtsev I. V.
1
,
Khotimchenko Yu S
1, 2
,
Zhidkov M E
1
,
Publication type: Journal Article
Publication date: 2018-03-25
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 0.7
ISSN: 00074888, 15738221, 03659615, 24131008
General Biochemistry, Genetics and Molecular Biology
General Medicine
Abstract
Antitumor efficiency of fascaplysin synthetic derivatives (7-phenylfascaplysin, 3-chlorofascaplysin, 3-bromofascaplysin, and 10-bromofascaplysin) was compared out in vitro on C6 glioma cells. The cytotoxic efficiency of all tested compounds was higher than that of unsubstituted fascaplysin; 3-bromofascaplysin and 7-phenylfascaplysin exhibited the best capacity to kill glioma C6 cells. Apoptosis was the main mechanism of glioma cell death. The cytotoxic activity of these compounds increased with prolongation of exposure to the substance and increase of its concentration. Fascaplysin derivatives modified all phases of glioma cell vital cycle. The count of viable tumor cell in G0 phase remained minimum by the end of experiment under the effects of 3-bromofascaplysin and 7-phenylfascaplysin.
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- We do not take into account publications that without a DOI.
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Lyakhova I. A. et al. Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro // Bulletin of Experimental Biology and Medicine. 2018. Vol. 164. No. 5. pp. 666-672.
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Lyakhova I. A., Bryukhovetsky I. S., Kudryavtsev I. V., Khotimchenko Yu. S., Zhidkov M. E., Kantemirov A. V. Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro // Bulletin of Experimental Biology and Medicine. 2018. Vol. 164. No. 5. pp. 666-672.
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TY - JOUR
DO - 10.1007/s10517-018-4055-4
UR - https://doi.org/10.1007%2Fs10517-018-4055-4
TI - Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro
T2 - Bulletin of Experimental Biology and Medicine
AU - Lyakhova, I A
AU - Bryukhovetsky, I S
AU - Kudryavtsev, I. V.
AU - Khotimchenko, Yu S
AU - Zhidkov, M E
AU - Kantemirov, A V
PY - 2018
DA - 2018/03/25 00:00:00
PB - Springer Nature
SP - 666-672
IS - 5
VL - 164
SN - 0007-4888
SN - 1573-8221
SN - 0365-9615
SN - 2413-1008
ER -
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@article{2018_Lyakhova,
author = {I A Lyakhova and I S Bryukhovetsky and I. V. Kudryavtsev and Yu S Khotimchenko and M E Zhidkov and A V Kantemirov},
title = {Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro},
journal = {Bulletin of Experimental Biology and Medicine},
year = {2018},
volume = {164},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1007%2Fs10517-018-4055-4},
number = {5},
pages = {666--672},
doi = {10.1007/s10517-018-4055-4}
}
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Lyakhova, I. A., et al. “Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro.” Bulletin of Experimental Biology and Medicine, vol. 164, no. 5, Mar. 2018, pp. 666-672. https://doi.org/10.1007%2Fs10517-018-4055-4.